Cyclo(L-Phe-L-Val)

• 常用名: Cyclo(L-Phe-L-Val)
• 英文名: Cyclo(L-Phe-L-Val)
• CAS号: 35590-86-4
• 分子量: 246.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₈N₂O₂
• 熔点: N/A
• 闪点: N/A

Cyclo(L-Phe-L-Val)用途

环(L-Phe-L-Val)是一种有效的异柠檬酸裂解酶(ICL)抑制剂(IC50=27μg/mL)。cyclo(L-Phe-L-Val)在C2碳利用条件下抑制白色念珠菌中ICL的基因转录[1]。

Cyclo(L-Phe-L-Val)名称

• 英文名: cis-cyclo(Val-Phe)

Cyclo(L-Phe-L-Val)生物活性

• 描述: 环(L-Phe-L-Val)是一种有效的异柠檬酸裂解酶(ICL)抑制剂(IC50=27μg/mL)。cyclo(L-Phe-L-Val)在C2碳利用条件下抑制白色念珠菌中ICL的基因转录[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 靶点实验:

  Isocitrate lyase (ICL)[1]

• 体外研究: 环(L-Phe-L-Val)(32μg/mL；2天)分别降低白色念珠菌 SC5314型(野生型)、MRC10(Δicl)和 MRC11(Δicl+icl)中的 icl公司产物水平[1]
• 参考文献:

  [1]. Kim H, et al. Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans. Molecules. 2019 Jun 4;24(11):2111.

Cyclo(L-Phe-L-Val)物理化学性质

• 分子式: C₁₄H₁₈N₂O₂
• 分子量: 246.30
• 精确质量: 246.13700
• PSA: 58.20000
• LogP: 1.52590
• InChIKey: OQQPOHUVAQPSHJ-RYUDHWBXSA-N
• SMILES: CC(C)C1NC(=O)C(Cc2ccccc2)NC1=O

Cyclo(L-Phe-L-Val)靶点实验

查看更多实验

实验名称：Antibiofilm activity against Fusobacterium nucleatum ATCC 25586 assessed as inhibitio... 来源：ChEMBL 靶标：Fusobacterium nucleatum External Id：CHEMBL4340591

实验名称：Antimalarial activity against schizonts of chloroquine-sensitive Plasmodium berghei A... 来源：ChEMBL 靶标：Plasmodium berghei External Id：CHEMBL2216561

实验名称：Antimalarial activity against schizonts of chloroquine-sensitive Plasmodium berghei A... 来源：ChEMBL 靶标：Plasmodium berghei External Id：CHEMBL2216562

实验名称：Inhibition of planktonic growth of Streptococcus mutans ATCC 25175 up to 96 ug/mL aft... 来源：ChEMBL 靶标：Streptococcus mutans External Id：CHEMBL4340620

实验名称：Antibiofilm activity against Streptococcus mutans ATCC 25175 assessed as inhibition o... 来源：ChEMBL 靶标：Streptococcus mutans External Id：CHEMBL4340610

实验名称：Antibiotic activity against Escherichia coli ATCC 25922 by agar diffusion method 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL971087

实验名称：Antibiotic activity against Bacillus subtilis ATCC 6633 by agar diffusion method 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL971086

实验名称：Antibiofilm activity against Porphyromonas gingivalis ATCC 33277 assessed as inhibiti... 来源：ChEMBL 靶标：Porphyromonas gingivalis External Id：CHEMBL4340592

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Cyclo(L-Phe-L-Val)英文别名

• Cyclo(Val-Phe)
• (3S,6S)-3-isopropyl-6-benzylpiperazine-2,5-dione
• (3S,6S)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione
• cyclo(L-phenylalanyl-L-valine)
• (S,S)-cyclo-Val-Phe
• (3S,6S)-3-benzyl-6-isopropyl-2,5-piperazinedione