甲地孕酮

• 常用名: 甲地孕酮
• 英文名: Megestrol
• CAS号: 3562-63-8
• 分子量: 342.472
• 密度: 1.2±0.1 g/cm3
• 沸点: 500.4±50.0 °C at 760 mmHg
• 分子式: C₂₂H₃₀O₃
• 熔点: N/A
• 闪点: 270.5±26.6 °C

甲地孕酮用途

【用途一】
可治疗痛经、功能性子宫出血、子宫内膜异位及子宫内膜腺癌。

甲地孕酮名称

• 中文名: 甲地孕酮
• 英文名: megestrol
• 中文别名: 甲地孕酮

甲地孕酮生物活性

• 描述: Megestrol 是一种合成的孕激素,用于患有获得性免疫缺陷综合症诊断的患者的厌食症,恶疾或无法解释的重大体重减轻。
• 参考文献:

  [1]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1.

甲地孕酮物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 500.4±50.0 °C at 760 mmHg
• 分子式: C₂₂H₃₀O₃
• 分子量: 342.472
• 闪点: 270.5±26.6 °C
• 精确质量: 342.219482
• PSA: 54.37000
• LogP: 3.06
• InChIKey: VXIMPSPISRVBPZ-NWUMPJBXSA-N
• SMILES: CC(=O)C1(O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C
• 外观性状: 白色固体
• 蒸汽压: 0.0±2.9 mmHg at 25°C
• 折射率: 1.569

甲地孕酮毒性和生态

甲地孕酮靶点实验

查看更多实验

实验名称：Binding affinity towards human ADRA2A in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5291736

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Binding affinity towards human PGR in an in vitro assay with cellular components meas... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5291863

实验名称：Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluor... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291731

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5291728

实验名称：Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5291856

实验名称：Binding affinity towards human OPRM1 in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5291855

实验名称：Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291730

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

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甲地孕酮英文别名

• MFCD01939877
• EINECS 222-628-6
• 17-Hydroxy-6-methyl-pregna-4,6-dien-3,20-dion
• 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
• 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE
• Megestrol
• 20-dione,17-hydroxy-6-methyl-pregna-6-diene-3