3562-63-8

• 常用中文名：甲地孕酮
• 常用英文名：Megestrol
• CAS号：3562-63-8
• 分子式：C₂₂H₃₀O₃
• 分子量：342.472
• 相关类别： 原料药 激素及调节内分泌功能类药 避孕药
• 发布时间：2018-04-15 08:00:00
• 更新时间：2026-07-05 11:00:36
• 【用途一】
  可治疗痛经、功能性子宫出血、子宫内膜异位及子宫内膜腺癌。

名称

• 中文名: 甲地孕酮
• 英文名: megestrol
• 中文别名: 醋酸甲地孕酮杂质B; 去氢甲地孕酮; 甲醇中甲地孕酮; 化合物:Megestrol; 甲地孕酮溶液,100PPM; 甲地孕酮(标准品); 乙腈中甲地孕酮; 化合物：Megestrol
• 英文别名: Megestrol Acetate Impurity 2(Megestrol Acetate Impurity B)(Megestrol); MFCD01939877; Megestrol 100 μg/ml Acetonitrile; 20-dione,17-hydroxy-6-methyl-pregna-6-diene-3; Megestrol //BP; Metesterone acetate impurity B; (8R,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-6,10,13-trimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one; Megesstrol; 17-ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE; 17α-Hydroxy-6-Methyl-4,6-Pregnadiene-3,20-Dione; MEGESTROL; Megestrol Acetate Impurity 2（Megestrol Acetate Impurity B）; 17-alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione; megestrol solution,100ppm; Megestrol in Methanol; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione; 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE; Megestro; Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl; EINECS 222-628-6; C07120; 17-Hydroxy-6-methyl-pregna-4,6-dien-3,20-dion; Megestrol (base and/or unspecified salts); Medroxyprogesterone Acetate Impurit 4 megestrol; Megestrol acetate Impurity B; 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 500.4±50.0 °C at 760 mmHg
• 分子式: C₂₂H₃₀O₃
• 分子量: 342.472
• 闪点: 270.5±26.6 °C
• 精确质量: 342.219482
• PSA: 54.37000
• LogP: 3.06
• 外观性状: 白色固体
• 蒸汽压: 0.0±2.9 mmHg at 25°C
• 折射率: 1.569

生物活性

• 描述: Megestrol 是一种合成的孕激素,用于患有获得性免疫缺陷综合症诊断的患者的厌食症,恶疾或无法解释的重大体重减轻。
• 参考文献:

  [1]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU4074500 CHEMICAL NAME : Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- CAS REGISTRY NUMBER : 3562-63-8 LAST UPDATED : 199606 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C22-H20-O3 MOLECULAR WEIGHT : 332.42 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg/15D-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport REFERENCE : SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 11(3),17,1991

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