神经节苷酯GM<sub>2</sub>结构式
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常用名 | 神经节苷酯GM<sub>2</sub> | 英文名 | Ganglioside GM2 Asialo Mixture |
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| CAS号 | 35960-33-9 | 分子量 | 1093.4 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C56H104N2O18 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
神经节苷酯GM<sub>2</sub>用途神经节苷脂GM2-asialo(asialo-GM2)是一种含三个单糖残基和一个可变链长脂肪酸的糖脂,但缺乏神经节苷脂M2上的唾液酸残基。Asialo-GM2在正常人脑中的水平较低或检测不到,但它在Tay-Sachs病和Sandhoff病患者的大脑中积累,这两种疾病表现为溶酶体β-一种以己糖胺酶A和B缺乏为特征的神经退行性疾病。它还与各种细菌结合,包括从囊性纤维化患者身上分离出来的假单胞菌。Asialo-GM2混合物含有神经节苷脂GM2 Asialo分子,具有可变长度的脂肪酰基链。 |
| 中文名 | 神经节苷酯GM<sub>2</sub> |
|---|---|
| 英文名 | Asialoganglioside GM<sub>2</sub> |
| 英文别名 | 更多 |
| 分子式 | C56H104N2O18 |
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| 分子量 | 1093.4 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 危险品运输编码 | NONH for all modes of transport |
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Asialo GM-2 developed on the fatty streak of atherosclerotic aorta detected by a novel monoclonal antibody (ASH1a/256C).
Ann. N. Y. Acad. Sci. 748 , 277-81; discussion 281-2, (1995)
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Catabolism of asialo-GM2 in man and mouse. Specificity of human/mouse chimeric GM2 activator proteins.
J. Biol. Chem. 274(40) , 28612-8, (1999) Tay-Sachs disease is an inborn lysosomal disease characterized by excessive cerebral accumulation of GM2. The catabolism of GM2 to GM3 in man requires beta-hexosaminidase A (HexA) and a protein cofact... |
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Optimal conditions to radiolabel (3H or 14C) aminosugar-containing glycosphingolipids by de-N-acetylation and re-N-acetylation.
Biochim. Biophys. Acta 1244(2-3) , 418-22, (1995) The optimal conditions were examined for selective re-N-acetylation with 14C or 3H.acetic anhydride of de-N-acetylated aminosugar-containing glycosphingolipids. Re-N-acetylation, which is nearly quant... |
| MFCD00131129 |
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