[Ala17]-MCH

• 常用名: [Ala17]-MCH
• 英文名: [Ala17]-MCH
• CAS号: 359784-84-2
• 分子量: 2271.707
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₉₇H₁₅₅N₂₉O₂₆S₄
• 熔点: N/A
• 闪点: N/A

[Ala17]-MCH用途

[Ala17]-MCH 是一种 MCH (HY-P1525A) 的类似物,是 MCHR1 的配体 (Ki=0.16 nM) 选择性 优于对 MCHR2 的 (Ki=34 nM)。Eu3+螯合标记 [Ala17]-MCH 对 MCHR1 (Kd=0.37 nM) 亲和性高,而对 MCHR2 的亲和性低。

[Ala17]-MCH名称

• 英文名: [Ala17]-MCH

[Ala17]-MCH生物活性

• 描述: [Ala17]-MCH 是一种 MCH (HY-P1525A) 的类似物,是 MCHR1 的配体 (Ki=0.16 nM) 选择性 优于对 MCHR2 的 (Ki=34 nM)。Eu3+螯合标记 [Ala17]-MCH 对 MCHR1 (Kd=0.37 nM) 亲和性高,而对 MCHR2 的亲和性低。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> MCHR1(GPR24)
  研究领域 >> 代谢疾病
• 靶点:

  Ki: 0.16 nM (MCHR1) Ki: 34 nM (MCHR2)[1]

• 参考文献:

  [1]. Xiaoying Gao, et al. Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal Biochem. 2004 May 15;328(2):187-95.

[Ala17]-MCH物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₉₇H₁₅₅N₂₉O₂₆S₄
• 分子量: 2271.707
• 精确质量: 2270.058105
• PSA: 1030.15000
• LogP: -2.38
• 折射率: 1.673

[Ala17]-MCH英文别名

• L-Argininamide, L-α-aspartyl-L-phenylalanyl-L-α-aspartyl-L-methionyl-L-leucyl-N-[(3R,8R,11S,14S,20S,23S,26S,29S,34aS)-3-[[[(1S)-2-[[(1S)-4-amino-1-[[[(1S)-1-carboxy-2-methylpropyl]amino]carbon yl]-4-oxobutyl]amino]-1-methyl-2-oxoethyl]amino]carbonyl]-20,29-bis[3-[(aminoiminomethyl)amino]propyl]dotriacontahydro-26-[(4-hydroxyphenyl)methyl]-23-(1-methylethyl)-14-(2-methylpropyl)-11-[2-(methyl thio)ethyl]-1,9,12,15,18,21,24,27,30-nonaoxo
• BU 239 hydrochloride
• (6S,9S,12S,15S,18S,21S)-1,21-Diamino-6-({(3R,8R,11S,14S,20S,23S,26S,29S,34aS)-3-{[(2S)-1-{[(2S)-5-amino-1-{[(1S)-1-carboxy-2-methylpropyl]amino}-1,5-dioxo-2-pentanyl]amino}-1-oxo-2-propanyl]carbamoyl}-20,29-bis(3-carbamimidamidopropyl)-26-(4-hydroxybenzyl)-14-isobutyl-23-isopropyl-11-[2-(methylsulfanyl)ethyl]-1,9,12,15,18,21,24,27,30-nonaoxodotriacontahydropyrrolo[2,1-g][1,2,5,8,11,14,17,20,23,26,29]dithianonaazacyclodotriacontin-8-yl}carba