八氢姜黄素

• 常用名: 八氢姜黄素
• 英文名: Octahydrocurcumin
• CAS号: 36062-07-4
• 分子量: 376.443
• 密度: 1.2±0.1 g/cm3
• 沸点: 623.5±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₈O₆
• 熔点: N/A
• 闪点: 330.9±31.5 °C

八氢姜黄素用途

八氢姜黄素(Octahydrocurcumin)是姜黄素的氢化衍生物,姜黄素的代谢物。

八氢姜黄素作用

在动物体内有利胆作用。对泥沙状胆结石有一定溶解作用。
 

八氢姜黄素名称

• 中文名: 八氢姜黄素
• 英文名: 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol

八氢姜黄素生物活性

• 描述: 八氢姜黄素(Octahydrocurcumin)是姜黄素的氢化衍生物,姜黄素的代谢物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
  天然产物 >> 酚类
• 参考文献:

  [1]. Deters M, et al. Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities. Pharm Res. 2008 Aug;25(8):1822-7.

  [2]. Zhao F, et al. Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential target. Mol Med Rep. 2015 Apr;11(4):3087-93.

  [3]. Somparn P, et al. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull. 2007 Jan;30(1):74-8.

八氢姜黄素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 623.5±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₈O₆
• 分子量: 376.443
• 闪点: 330.9±31.5 °C
• 精确质量: 376.188599
• PSA: 99.38000
• LogP: 1.73
• InChIKey: OELMAFBLFOKZJD-UHFFFAOYSA-N
• SMILES: COc1cc(CCC(O)CC(O)CCc2ccc(O)c(OC)c2)ccc1O
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.592
• 储存条件: -20°C

八氢姜黄素靶点实验

查看更多实验

实验名称：Antitrypanosomal activity against multidrug-resistant Trypanosoma brucei brucei B48 a... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL1099526

实验名称：Antitrypanosomal activity against diminazene-resistant Trypanosoma brucei brucei delt... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL1099525

实验名称：Antitrypanosomal activity against Trypanosoma brucei brucei 427 after 48 hrs by alama... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL1099524

实验名称：Activation of human telomerase activity expressed in HEK293T cells incubated for 30 m... 来源：ChEMBL 靶标：Telomerase reverse transcriptase External Id：CHEMBL3384591

实验名称：Inhibition of HDAC in human HeLa cell nuclear extract assessed as residual activity a... 来源：ChEMBL 靶标：Histone deacetylase 5 External Id：CHEMBL4620512

实验名称：Inhibition of recombinant BACE1 (unknown origin) 来源：ChEMBL 靶标：Beta-secretase 1 External Id：CHEMBL3107152

实验名称：Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL1099529

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 200 ug/ml afte... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL1252096

实验名称：Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 amastigotes afte... 来源：ChEMBL 靶标：Leishmania mexicana External Id：CHEMBL1099528

实验名称：Antileishmanial activity against Leishmania major Friedlin promastigotes after 48 hrs... 来源：ChEMBL 靶标：Leishmania major External Id：CHEMBL1099527

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八氢姜黄素英文别名

• 1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol
• Curcumin bis-acetate
• octahydrocurcumin
• Curcumin 4,4'-diacetate
• 1,6-Heptadiene-3,5-dione,1,7-bis(4-(acetyloxy)-3-methoxyphenyl)
• 1,7-bis(4-acetoxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
• hexahydrocurcuminol
• diacetyldiferuloylmethane
• diacetylcurcumin
• 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol
• curcumin acetic acid ester (diacetylated)
• 1,7-bis(4-acetoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
• 4,4'-Diacetylcurcumin
• Di-O-Acetylcurcumin
• Acetic acid,4-[7-(4-acetoxy-3-methoxy-phenyl)-3,5-dioxo-hepta-1,6-dienyl]-2-methoxy-phenyl ester
• 1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione