Octahydrocurcumin

Modify Date: 2025-08-20 20:42:36

Octahydrocurcumin structure	Common Name	Octahydrocurcumin
	CAS Number	36062-07-4	Molecular Weight	376.443
	Density	1.2±0.1 g/cm3	Boiling Point	623.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₈O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	330.9±31.5 °C

Use of Octahydrocurcumin

Octahydrocurcumin is a hydrogenated derivatives of curcumin; metabolite of curcumin.IC50 value:Target: OKT3-induced PBMC proliferation was inhibited by octahydrocurcumin with IC50 of 82 uM. The investigated substances with the strongest effect on radical scavenging were tetrahydro-, hexahydro-, and octahydrocurcumin with IC50 values of 10.0, 11.7, and 12.3 microM, respectively [1]. curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor?α (TNF?α) and interleukin?6 (IL?6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release [2]. Hydrogenated derivatives of curcumin exhibited stronger DPPH scavenging activity compared to curcumin and a reference antioxidant, trolox. The scavenging activity significantly decreased in the order THC>HHC=OHC>trolox>curcumin>Dmc>>>Bdmc [3].

Name	1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol
Synonym	More Synonyms

Description	Octahydrocurcumin is a hydrogenated derivatives of curcumin; metabolite of curcumin.IC50 value:Target: OKT3-induced PBMC proliferation was inhibited by octahydrocurcumin with IC50 of 82 uM. The investigated substances with the strongest effect on radical scavenging were tetrahydro-, hexahydro-, and octahydrocurcumin with IC50 values of 10.0, 11.7, and 12.3 microM, respectively [1]. curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor?α (TNF?α) and interleukin?6 (IL?6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release [2]. Hydrogenated derivatives of curcumin exhibited stronger DPPH scavenging activity compared to curcumin and a reference antioxidant, trolox. The scavenging activity significantly decreased in the order THC>HHC=OHC>trolox>curcumin>Dmc>>>Bdmc [3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenols
References	[1]. Deters M, et al. Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities. Pharm Res. 2008 Aug;25(8):1822-7. [2]. Zhao F, et al. Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential target. Mol Med Rep. 2015 Apr;11(4):3087-93. [3]. Somparn P, et al. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull. 2007 Jan;30(1):74-8.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Phenols

References

[1]. Deters M, et al. Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities. Pharm Res. 2008 Aug;25(8):1822-7.

[2]. Zhao F, et al. Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential target. Mol Med Rep. 2015 Apr;11(4):3087-93.

[3]. Somparn P, et al. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull. 2007 Jan;30(1):74-8.

Density	1.2±0.1 g/cm3
Boiling Point	623.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₈O₆
Molecular Weight	376.443
Flash Point	330.9±31.5 °C
Exact Mass	376.188599
PSA	99.38000
LogP	1.73
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.592
InChIKey	OELMAFBLFOKZJD-UHFFFAOYSA-N
SMILES	COc1cc(CCC(O)CC(O)CCc2ccc(O)c(OC)c2)ccc1O
Storage condition	-20°C

1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol

Curcumin bis-acetate

octahydrocurcumin

Curcumin 4,4'-diacetate

1,6-Heptadiene-3,5-dione,1,7-bis(4-(acetyloxy)-3-methoxyphenyl)

1,7-bis(4-acetoxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

hexahydrocurcuminol

diacetyldiferuloylmethane

diacetylcurcumin

3,5-Heptanediol, 1,7-bis(4-hydroxy-3-methoxyphenyl)-

1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol

curcumin acetic acid ester (diacetylated)

1,7-bis(4-acetoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

4,4'-Diacetylcurcumin

Di-O-Acetylcurcumin

Acetic acid,4-[7-(4-acetoxy-3-methoxy-phenyl)-3,5-dioxo-hepta-1,6-dienyl]-2-methoxy-phenyl ester

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Octahydrocurcumin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Octahydrocurcumin
Price: ￥1968.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Octahydrocurcumin
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Octahydrocurcumin
Price: $800.0/100mg $1600.0/250mg $3200.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Octahydrocurcumin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $205/10mM*1mLinDMSO

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Octahydrocurcumin

Use of Octahydrocurcumin

Names

Octahydrocurcumin Biological Activity

Chemical & Physical Properties

Synonyms

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