5反式前列腺素F2α

• 常用名: 5反式前列腺素F2α
• 英文名: Prostaglandin F2α
• CAS号: 36150-01-3
• 分子量: 354.481
• 密度: 1.2±0.1 g/cm3
• 沸点: 531.0±50.0 °C at 760 mmHg
• 分子式: C₂₀H₃₄O₅
• 熔点: N/A
• 闪点: 289.0±26.6 °C

5反式前列腺素F2α用途

5-反式前列腺素F2α是血液中存在的内源性代谢产物,可用于心肌梗死的研究[1][2]。

5反式前列腺素F2α名称

• 中文名: 5反式前列腺素F2α
• 英文名: 5-trans Prostaglandin F2.α.

5反式前列腺素F2α生物活性

• 描述: 5-反式前列腺素F2α是血液中存在的内源性代谢产物,可用于心肌梗死的研究[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
• 体外研究: 内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。
• 参考文献:

  [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

  [2]. Strohmenger HU, et al. Concentrations of prolactin and prostaglandins during and after cardiopulmonary resuscitation. Crit Care Med. 1995 Aug;23(8):1347-55.

5反式前列腺素F2α物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 531.0±50.0 °C at 760 mmHg
• 分子式: C₂₀H₃₄O₅
• 分子量: 354.481
• 闪点: 289.0±26.6 °C
• 精确质量: 354.240631
• PSA: 97.99000
• LogP: 2.14
• InChIKey: PXGPLTODNUVGFL-UAAPODJFSA-N
• SMILES: CCCCCC(O)C=CC1C(O)CC(O)C1CC=CCCCC(=O)O
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.569

5反式前列腺素F2α靶点实验

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实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Vibrio cholerae assay for pro-quorum sensing small molecules 来源：Southern Research Specialized Biocontainment Screening Center 靶标：cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961] External Id：Vcholera_QS_Pilot

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Primary qHTS for Vero E6 cytotoxicity: counterscreen for inhibitors of SARS-S pseudo-... 来源：NCGC 靶标：N/A External Id：TRND-SARS-cytotox-48hr-p1-npc

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5反式前列腺素F2α英文别名

• 5-trans prostaglandin f2alpha
• (5E,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid
• Prostaglandin F2α
• 9alpha,11alpha,15s-trihydroxy-prosta-5e,13e-dien-1-oic acid