NVP-231

• 常用名: NVP-231
• 英文名: NVP 231
• CAS号: 362003-83-6
• 分子量: 431.550
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₅H₂₅N₃O₂S
• 熔点: N/A
• 闪点: N/A

NVP-231用途

NVP-231是高效可逆的CerK抑制剂，IC50为12 nM，能竞争性抑制神经酰胺与CerK的结合。

NVP-231名称

• 中文名: NVP 231
• 英文名: N-(2-benzamido-1,3-benzothiazol-6-yl)adamantane-1-carboxamide

NVP-231生物活性

• 描述: NVP-231是高效可逆的CerK抑制剂,IC50为12 nM,能竞争性抑制神经酰胺与CerK的结合。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Graf C, et al. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008 Oct;74(4):925-32.

  [2]. Graf C, et al. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal Biochem. 2009 Jan 1;384(1):166-9.

NVP-231物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₅H₂₅N₃O₂S
• 分子量: 431.550
• 精确质量: 431.166748
• PSA: 99.33000
• LogP: 5.34
• InChIKey: MVSSJPGNLQPWSW-UHFFFAOYSA-N
• SMILES: O=C(Nc1nc2ccc(NC(=O)C34CC5CC(CC(C5)C3)C4)cc2s1)c1ccccc1
• 折射率: 1.743
• 储存条件: 2~8°C，密封

NVP-231安全信息

• 危险品运输编码: NONH for all modes of transport

NVP-231靶点实验

查看更多实验

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL5303715

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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NVP-231英文别名

• nvp-231
• (3s,5s,7s)-N-[2-(Benzoylamino)-1,3-benzothiazol-6-yl]-1-adamantanecarboxamide
• N-[2-(Benzoylamino)-1,3-benzothiazol-6-yl]-1-adamantanecarboxamide
• NVP 231