药根碱

• 常用名: 药根碱
• 英文名: Jatrorrhizine
• CAS号: 3621-38-3
• 分子量: 338.377
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₀NO₄+
• 熔点: N/A
• 闪点: N/A
• 符号: GHS09
• 信号词: Warning

药根碱用途

Jatrorrhizine 是一种有效的口服活性 uptake-2 transporter 抑制剂,可以从各种中药植物中分离出来。 Jatrorrhizine 通过抑制 HT22 海马神经元中的 MAPK 途径,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用。

药根碱名称

• 中文名: 药根碱
• 英文名: 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
• 中文别名: 藥根鹼

药根碱生物活性

• 描述: Jatrorrhizine 是一种有效的口服活性 uptake-2 transporter 抑制剂,可以从各种中药植物中分离出来。 Jatrorrhizine 通过抑制 HT22 海马神经元中的 MAPK 途径,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
• 靶点实验:

  Uptake-2 transporter[1]

• 体外研究: 有机阳离子转运蛋白(OCTs)和质膜单胺转运蛋白(PMAT)是主要的摄取-2转运蛋白[1]。Jatrorhizine以浓度依赖性方式显着抑制质膜单胺转运蛋白(PMAT)介导的MPP+摄取,IC50值为1.05μM[1]。Jatrorhizine对hOCT2和hOCT3介导的5-羟色胺(5-HT)和去甲肾上腺素(NE)摄取的抑制作用比PMAT介导的更强[1]。Jatrorhizine减弱这些神经元中H2O2诱导的Bcl-2/Bax比值降低和caspase-3活化[2]。
• 参考文献:

  [1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.

药根碱物理化学性质

• 分子式: C₂₀H₂₀NO₄+
• 分子量: 338.377
• 精确质量: 338.138672
• PSA: 51.80000
• LogP: -1.89
• InChIKey: MXTLAHSTUOXGQF-UHFFFAOYSA-O
• SMILES: COc1cc2c(cc1O)CC[n+]1cc3c(OC)c(OC)ccc3cc1-2
• 储存条件: 2-8°C

药根碱安全信息

• 符号: GHS09
• 信号词: Warning
• 危害声明: H400
• 警示性声明: P273
• 危害码 (欧洲): N
• 风险声明 (欧洲): 50
• 安全声明 (欧洲): 61
• 危险品运输编码: UN 3077 9 / PGIII
• 海关编码: 2933990090

药根碱海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

药根碱靶点实验

查看更多实验

实验名称：C. difficile toxins: Counterscreen in absence of substrate UDPG Measured in Biochemic... 来源：Broad Institute 靶标：N/A External Id：7074-02_Inhibitor_Dose_CherryPick_Activity

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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药根碱英文别名

• Neprotine
• YATROIZINE HCL
• Neprotin
• 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
• 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium
• NEPROTINE IODIDE
• Jateorrhizine
• Jatrorrhizine
• jatorrhizine
• Jateorhizine
• Jatrorrhizin
• NEPROTINE HCL
• 7,8,13,13a-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium
• Yatrorizine