1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐

• 常用名: 1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐
• 英文名: 4-Piperidone, 1-hydroxy-2,2,6,6-tetramethyl
• CAS号: 3637-11-4
• 分子量: 171.23700
• 密度: 1.02g/cm3
• 沸点: 257.5ºC at 760mmHg
• 分子式: C₉H₁₇NO₂
• 熔点: N/A
• 闪点: 109.5ºC

1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐用途

Tempone-H可用作化学和生物系统中的自旋陷阱,以量化过亚硝酸根和超氧自由基的形成。铁离子和铜离子是Tempone-H[1][2]的有效氧化剂。

1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐名称

• 中文名: 1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐
• 英文名: 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-one

1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐生物活性

• 描述: Tempone-H可用作化学和生物系统中的自旋陷阱,以量化过亚硝酸根和超氧自由基的形成。铁离子和铜离子是Tempone-H[1][2]的有效氧化剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体外研究: 使用TEMPONE-H检测过氧亚硝酸盐或超氧自由基的灵敏度约为使用自旋陷阱DMPO或TMIO的10倍[1]。
• 参考文献:

  [1]. Dikalov S, et al. Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. Biochem Biophys Res Commun. 1997 Jan 3;230(1):54-7.

  [2]. Dikalov SI, et al. Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. J Biol Chem. 1999 Apr 2;274(14):9392-9.

1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐物理化学性质

• 密度: 1.02g/cm3
• 沸点: 257.5ºC at 760mmHg
• 分子式: C₉H₁₇NO₂
• 分子量: 171.23700
• 闪点: 109.5ºC
• 精确质量: 171.12600
• PSA: 40.54000
• LogP: 1.53560
• InChIKey: KMEUSKGEUADGET-UHFFFAOYSA-N
• SMILES: CC1(C)CC(=O)CC(C)(C)N1O
• 储存条件: -20°C

1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐安全信息

• 海关编码: 2933399090

1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐靶点实验

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实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas... 来源：Broad Institute 靶标：N/A External Id：2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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1-羟基-2,2,6,6-四甲基-4-氧-哌啶盐酸盐英文别名

• 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one
• 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine
• 4-oxo-TEMPO-H
• 4-Piperidinone,1-hydroxy-2,2,6,6-tetramethyl
• 1-Hydroxy-2,2,6,6-tetramethyl-piperidin-4-on
• 2,2,6,6-tetramethyl-4-oxo-1-piperidinyloxy
• Tempone-H
• N-hydroxy-4-oxo-2,2,6,6-tetramethylpiperidine
• 1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone