LPA2 antagonist 2

• 常用名: LPA2 antagonist 2
• 英文名: LPA2 antagonist 2
• CAS号: 36840-10-5
• 分子量: 380.35100
• 密度: 1.444±0.06 g/cm3(Predicted)
• 沸点: 758.0±60.0 °C(Predicted)
• 分子式: C₂₀H₁₆N₂O₆
• 熔点: N/A
• 闪点: N/A

LPA2 antagonist 2用途

LPA2 antagonist 2 (H2L 5226501) 是一种选择性 LPA2 拮抗剂,IC50 为 28.3 nM,比 LPA3 (IC50 为 13.85 μM) 选择性高 480 倍以上。

LPA2 antagonist 2名称

• 中文名: 4,4'-(4,4'-联苯二亚氨基)双(4-氧代-2-丁烯酸)
• 英文名: 4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)

LPA2 antagonist 2生物活性

• 描述: LPA2 antagonist 2 (H2L 5226501) 是一种选择性 LPA2 拮抗剂,IC50 为 28.3 nM,比 LPA3 (IC50 为 13.85 μM) 选择性高 480 倍以上。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
• 靶点实验:

  IC50: 28.3 nM (LPA2); 13.85 μM (LPA3)[1]

• 参考文献:

  [1]. Fells JI, et al. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17.

LPA2 antagonist 2物理化学性质

• 密度: 1.444±0.06 g/cm3(Predicted)
• 沸点: 758.0±60.0 °C(Predicted)
• 分子式: C₂₀H₁₆N₂O₆
• 分子量: 380.35100
• 精确质量: 380.10100
• PSA: 132.80000
• LogP: 2.65820
• InChIKey: FTLRWRKPUWMOMS-WGDLNXRISA-N
• SMILES: O=C(O)C=CC(=O)Nc1ccc(-c2ccc(NC(=O)C=CC(=O)O)cc2)cc1
• 储存条件: 2-8°C

LPA2 antagonist 2靶点实验

查看更多实验

实验名称：Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors of a ChemBridg... 来源：1102 靶标：N/A External Id：20130627FPNS3INTERFERECB

实验名称：Activity at LPA4 receptor expressed in CHO cells assessed as inhibition of LPA-induce... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 4 External Id：CHEMBL955648

实验名称：Activity at LPA5 receptor expressed in rat RH7777 cells assessed as inhibition of LPA... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 5 External Id：CHEMBL955649

实验名称：Fluorescence polarization based primary biochemical high throughput screening assay o... 来源：1102 靶标：NS3 [Hepatitis C virus] External Id：20130624FPNS3DACB

实验名称：Antagonist activity at LPA3 receptor expressed in rat RH7777 cells assessed as inhibi... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 3 External Id：CHEMBL955645

实验名称：Activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 1 External Id：CHEMBL955642

实验名称：Antagonist activity at LPA2 receptor expressed in rat RH7777 cells assessed as inhibi... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 2 External Id：CHEMBL955643

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LPA2 antagonist 2英文别名

• MFCD00566434