Ro 08-2750

• 常用名: Ro 08-2750
• 英文名: RO 08-2750
• CAS号: 37854-59-4
• 分子量: 270.243
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₃H₁₀N₄O₃
• 熔点: N/A
• 闪点: N/A

Ro 08-2750用途

Ro 08-2750 是一种非肽、可逆的 NGF 抑制剂,能直接结合 NGF,IC50 值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75NTR 的优于 TRKA。

Ro 08-2750名称

• 英文名: 7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde

Ro 08-2750生物活性

• 描述: Ro 08-2750 是一种非肽、可逆的 NGF 抑制剂,能直接结合 NGF,IC50 值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75NTR 的优于 TRKA。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: ~ 1 µM (NGF)[1]

• 体外研究: Ro 08-2750与NGF二聚体结合,因此可能导致其构象的改变,使得NGF不再与p75NTR结合[2]。Ro 08-2750(10nm)完全拯救了NGF诱导的SK-N-MC 103细胞死亡[2]。
• 参考文献:

  [1]. Arkin MR, et al. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr;3(4):301-17.

  [2]. Niederhauser O, et al. NGF ligand alters NGF signaling via p75(NTR) and trkA. J Neurosci Res. 2000 Aug 1;61(3):263-72.

Ro 08-2750物理化学性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₁₃H₁₀N₄O₃
• 分子量: 270.243
• 精确质量: 270.075287
• PSA: 97.71000
• LogP: -0.81
• InChIKey: JDEMVNYMYPJJIM-UHFFFAOYSA-N
• SMILES: Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C)c2cc1C=O
• 折射率: 1.754
• 储存条件: 2-8°C，干燥，密封

Ro 08-2750安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

Ro 08-2750海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Ro 08-2750靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrat... 来源：ChEMBL 靶标：Tyrosyl-DNA phosphodiesterase 2 External Id：CHEMBL2423658

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Inhibition of mouse NGF binding to TrkA (unknown origin) by SPR method relative to co... 来源：ChEMBL 靶标：High affinity nerve growth factor receptor External Id：CHEMBL3861736

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

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Ro 08-2750英文别名

• 7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde