RBC6

• 常用名: RBC6
• 英文名: RBC6
• CAS号: 381186-64-7
• 分子量: 365.214
• 密度: 1.6±0.1 g/cm3
• 沸点: 544.8±50.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄Cl₂N₄O₂
• 熔点: N/A
• 闪点: 283.3±30.1 °C

RBC6用途

RBC6 是 GTPases RalA 的抑制剂。RBC6 抑制 Ral 与其效应子 RALBP1 的结合。RBC6 还抑制 Ral 介导的小鼠胚胎成纤维细胞的细胞扩散,以及抑制人类癌细胞系的贴壁依赖性生长。

RBC6名称

• 英文名: 6-Amino-4-(3,5-dichloro-2-hydroxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

RBC6生物活性

• 描述: RBC6 是 GTPases RalA 的抑制剂。RBC6 抑制 Ral 与其效应子 RALBP1 的结合。RBC6 还抑制 Ral 介导的小鼠胚胎成纤维细胞的细胞扩散,以及抑制人类癌细胞系的贴壁依赖性生长。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Yan C, et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7.

RBC6物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 544.8±50.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄Cl₂N₄O₂
• 分子量: 365.214
• 闪点: 283.3±30.1 °C
• 精确质量: 364.049377
• LogP: 3.75
• InChIKey: NFPWWZIRTMIQKT-UHFFFAOYSA-N
• SMILES: CCCc1[nH]nc2c1C(c1cc(Cl)cc(Cl)c1O)C(C#N)=C(N)O2
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.691

RBC6靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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RBC6英文别名

• 6-Amino-4-(3,5-dichloro-2-hydroxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile