NSC668394

• 常用名: NSC668394
• 英文名: NSC668394
• CAS号: 382605-72-3
• 分子量: 452.097
• 密度: 1.9±0.1 g/cm3
• 沸点: 575.1±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂Br₂N₂O₃
• 熔点: N/A
• 闪点: 301.6±30.1 °C

NSC668394用途

NSC668394(NSC 668394)是ezrin的小分子抑制剂,直接与ezrin结合,Kd为12.59 uM；抑制内源性ezrin在10μM时的T567磷酸化和肌动蛋白结合,不改变细胞ezrin水平,抑制重组ezrin的PKC-1磷酸化IC50为8.1 uM；抑制ezrin介导的K7M2 OS细胞侵袭,在斑马鱼和非洲爪蟾胚胎发育过程中抑制细胞运动；还抑制小鼠肺中埃兹蛋白依赖性体内OS转移生长。

NSC668394名称

• 英文名: 7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione

NSC668394生物活性

• 描述: NSC668394(NSC 668394)是ezrin的小分子抑制剂,直接与ezrin结合,Kd为12.59 uM；抑制内源性ezrin在10μM时的T567磷酸化和肌动蛋白结合,不改变细胞ezrin水平,抑制重组ezrin的PKC-1磷酸化IC50为8.1 uM；抑制ezrin介导的K7M2 OS细胞侵袭,在斑马鱼和非洲爪蟾胚胎发育过程中抑制细胞运动；还抑制小鼠肺中埃兹蛋白依赖性体内OS转移生长。
• 参考文献: References 1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81. View Related Products by Target Ezrin

NSC668394物理化学性质

• 密度: 1.9±0.1 g/cm3
• 沸点: 575.1±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂Br₂N₂O₃
• 分子量: 452.097
• 闪点: 301.6±30.1 °C
• 精确质量: 449.921448
• LogP: 3.65
• InChIKey: OHPHDPYJEHZGDE-UHFFFAOYSA-N
• SMILES: O=C1C=C(NCCc2cc(Br)c(O)c(Br)c2)C(=O)c2ncccc21
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.729
• 储存条件: 2-8°C，干燥，密封

NSC668394安全信息

• 危害码 (欧洲): Xi

NSC668394靶点实验

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实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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实验名称：Inhibitory Activity against Recombinant Human PTP1 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL756368

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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NSC668394英文别名

• 7-{[2-(3,5-Dibromo-4-hydroxyphenyl)ethyl]amino}-5,8-quinolinedione
• 7-((2-(3,5-dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione