17-phenyl trinor Prostaglandin F2α methyl ester

• 常用名: 17-phenyl trinor Prostaglandin F2α methyl ester
• 英文名: Bimatoprost acid methyl ester
• CAS号: 38315-47-8
• 分子量: 402.524
• 密度: 1.2±0.1 g/cm3
• 沸点: 557.2±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₄O₅
• 熔点: N/A
• 闪点: 184.0±23.6 °C

用途

比马前列素甲酯是比马前列腺素(HY-B0191)的前药[1]。

名称

• 中文名: (Z)-7-[(1r,2r,3r,5s)-3,5-二羟基-2-((e)-(s)-3-羟基-5-苯基-1-戊烯)-环戊基]-5-庚烯酸甲酯
• 英文名: (z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-((e)-(s)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid methyl ester

生物活性

• 描述: 比马前列素甲酯是比马前列腺素(HY-B0191)的前药[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Balapure AK, et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochem Pharmacol. 1989 Jul 15;38(14):2375-81.

物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 557.2±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₄O₅
• 分子量: 402.524
• 闪点: 184.0±23.6 °C
• 精确质量: 402.240631
• PSA: 86.99000
• LogP: 2.68
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.591

英文别名

• 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, methyl ester, (5Z)-
• Methyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}hept-5-enoate
• BiMatoprost Acid Methyl Ester
• (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-((S)-(E)-3-hydroxy-5-phenylpent-1-enyl)-cyclopentyl]hept-5-enoic acid methyl ester
• Methyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-5-heptenoate
• (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-; 2-((E)-(S)-3-hydroxy-5-phenyl-pent-; 1-enyl)-cyclopentyl]-hept-5-enoic a; cid methyl ester
• (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-((S)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid methylester
• methyl ester of bimatoprost acid