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孕二烯二酮

更新时间:2025-08-24 22:02:41

孕二烯二酮结构式
孕二烯二酮结构式
品牌特惠专场
常用名 孕二烯二酮 英文名 (E)-Guggulsterone
CAS号 39025-24-6 分子量 312.446
密度 1.1±0.1 g/cm3 沸点 463.3±45.0 °C at 760 mmHg
分子式 C21H28O2 熔点 170-171.5°
MSDS 中文版 美版 闪点 172.3±25.7 °C
符号 GHS07
GHS07
信号词 Warning

 孕二烯二酮用途


(-)-(E)-古古尔甾酮是Z-古尔甾酮的代谢产物。Guggulsterone是guggulipid的一种活性成分,guggulipid是一种阿育吠陀药物,来源于Commiphora mukul。Guggulsterone具有降血脂活性[1]。

 孕二烯二酮名称

中文名 孕二烯二酮
英文名 (E)-Guggulsterone
中文别名 反式-固甾酮 | (17E)-孕甾-4,17(20)-二烯-3,16-二酮
英文别名 更多

 孕二烯二酮生物活性

描述 (-)-(E)-古古尔甾酮是Z-古尔甾酮的代谢产物。Guggulsterone是guggulipid的一种活性成分,guggulipid是一种阿育吠陀药物,来源于Commiphora mukul。Guggulsterone具有降血脂活性[1]。
相关类别
参考文献

[1]. N. VERMA, et al. Pharmacokinetics of Guggulsterone after Intravenous and Oral Administration in Rats.

 孕二烯二酮物理化学性质

密度 1.1±0.1 g/cm3
沸点 463.3±45.0 °C at 760 mmHg
熔点 170-171.5°
分子式 C21H28O2
分子量 312.446
闪点 172.3±25.7 °C
精确质量 312.208923
PSA 34.14000
LogP 3.65
InChIKey WDXRGPWQVHZTQJ-AUKWTSKRSA-N
SMILES CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
蒸汽压 0.0±1.1 mmHg at 25°C
折射率 1.557
储存条件 室温

 孕二烯二酮安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H335
警示性声明 P261
危害码 (欧洲) Xi
风险声明 (欧洲) 37-52/53
安全声明 (欧洲) 61-36
危险品运输编码 NONH for all modes of transport

 孕二烯二酮文献29

更多文献
Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.

Biochim. Biophys. Acta 1844(9) , 1684-93, (2014)

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative...

Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation.

Int. Immunopharmacol. 26 , 194-202, (2015)

Guggulsterone (GS), a plant steroid and a compound found at high levels in Commiphora myrrha, exhibits anti-inflammatory, anti-cancer, and cholesterol-lowering effects. However, the potential of GS to...

CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.

Mol. Pharmacol. 87(5) , 878-89, (2015)

Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression ...

 孕二烯二酮靶点实验

查看更多实验

实验名称:Cell Viability Profiling of Human Lymphoblast Cell Lines
来源:NCGC
靶标:N/A
External Id:HAPV101
实验名称:Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines
来源:NCGC
靶标:N/A
External Id:HAPC101
实验名称:Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
来源:23265
External Id:IucA Pilot Assay Tocris Library
实验名称:p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
来源:824
靶标:N/A
External Id:P53600
实验名称:p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
来源:824
靶标:N/A
External Id:P53MS958
实验名称:p53 small molecule agonists, cell-based qHTS assay
来源:824
External Id:P53344
实验名称:p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
来源:824
靶标:tumor suppressor p53 [Homo sapiens]
External Id:P53MS233
实验名称:Antiadipogenic activity in mouse 3T3L1 cells assessed as inhibition of CDCA-induced i...
来源:ChEMBL
靶标:3T3-L1
External Id:CHEMBL4144826
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 孕二烯二酮英文别名

Z-guggulsterone
UNII:9B259YE66O
E-guggulsterone
trans-Guggulsterone
Guggulsterone
(17E)-Pregna-4,17-diene-3,16-dione
(17E)-Pregna-4,17(20)-diene-3,16-dione
GUGGULSTERONE E
GS,TRANS
GUGGULESTERONE E
Z-Guggulsteron
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