EBV lytic cycle inducer-1

• 常用名: EBV lytic cycle inducer-1
• 英文名: EBV lytic cycle inducer-1
• CAS号: 394668-43-0
• 分子量: 318.17
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₂BrN₃O
• 熔点: N/A
• 闪点: N/A

EBV lytic cycle inducer-1用途

Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (Compound C7) 是一种类似铁螯合物的化合物。Dp44mT 可与 HDAC 抑制剂 Romidespin (HY-15149) 和 SAHA 协同诱导 EBV 裂解循环。Dp44mT 在上皮癌中通过激活 ERK1/2-自噬 (autophage) 轴重新激活 EBV 裂解周期。

EBV lytic cycle inducer-1名称

• 英文名: EBV lytic cycle inducer-1

EBV lytic cycle inducer-1生物活性

• 描述: Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (Compound C7) 是一种类似铁螯合物的化合物。Dp44mT 可与 HDAC 抑制剂 Romidespin (HY-15149) 和 SAHA 协同诱导 EBV 裂解循环。Dp44mT 在上皮癌中通过激活 ERK1/2-自噬 (autophage) 轴重新激活 EBV 裂解周期。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994.

  [2]. Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.

EBV lytic cycle inducer-1物理化学性质

• 分子式: C₁₄H₁₂BrN₃O
• 分子量: 318.17
• InChIKey: GZJPBATWGXWPLE-LICLKQGHSA-N
• SMILES: CC(=NNC(=O)c1cccc(Br)c1)c1ccccn1
• 储存条件: 2-8°C

EBV lytic cycle inducer-1靶点实验

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