柏木双黄酮

• 常用名: 柏木双黄酮
• 英文名: Cupressuflavone
• CAS号: 3952-18-9
• 分子量: 538.46
• 密度: N/A
• 沸点: 1083.4ºC at 760mmHg
• 分子式: C₃₀H₁₈O₁₀
• 熔点: >400ºC
• 闪点: 609ºC

柏木双黄酮用途

咖啡黄酮是一种天然产物,可以在大果咖啡中找到。咖啡黄酮具有抗炎和抗溃疡的活性。Cupressuflavone对CCl4诱导的小鼠肝肾毒性也具有保护作用[1][2][3]。

柏木双黄酮名称

• 中文名: 柏木双黄酮
• 英文名: cupressuflavone

柏木双黄酮生物活性

• 描述: 咖啡黄酮是一种天然产物,可以在大果咖啡中找到。咖啡黄酮具有抗炎和抗溃疡的活性。Cupressuflavone对CCl4诱导的小鼠肝肾毒性也具有保护作用[1][2][3]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 咖啡黄酮(40-160 mg/kg；口服,每天一次,持续5天)在肝脏和肾脏组织中通过增强抗氧化防御状态、减少脂质过氧化和防止 四氯化碳诱导的病理变化来对抗氧化应激[1] 咖啡黄酮(40-160 mg/kg；口服)在40、100、160毫克/千克剂量下分别抑制角叉菜胶诱导的炎症爪水肿 55%、60%和 64%[2]
• 参考文献:

  [1]. Al-Sayed E, et, al. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta Med. 2014 Dec;80(18):1665-71.

  [2]. Al-Sayed E, et, al. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug Dev Res. 2018 Feb;79(1):22-28.

  [3]. Koriem KMM, et, al. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol. 2015 Mar;8(1):25-34.

柏木双黄酮物理化学性质

• 沸点: 1083.4ºC at 760mmHg
• 熔点: >400ºC
• 分子式: C₃₀H₁₈O₁₀
• 分子量: 538.46
• 闪点: 609ºC
• 精确质量: 538.09000
• PSA: 181.80000
• LogP: 5.13400
• InChIKey: LADPNODMUXOPRG-UHFFFAOYSA-N
• SMILES: O=c1cc(-c2ccc(O)cc2)oc2c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c(O)cc(O)c12
• 折射率: 1.793
• 储存条件: 2-8°C，密封，干燥

柏木双黄酮靶点实验

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实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

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柏木双黄酮英文别名

• 8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-8-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• 8,8'-Biapigenin
• Cupressuflavone