WAY-270599

• 常用名: WAY-270599
• 英文名: WAY-270599
• CAS号: 397281-20-8
• 分子量: 374.8
• 密度: 1.651±0.06 g/cm3(Predicted)
• 沸点: N/A
• 分子式: C₁₇H₁₁ClN₂O₄S
• 熔点: N/A
• 闪点: N/A

WAY-270599用途

EJMC-1是一种中等强度的TNF-α抑制剂,IC50值为42μM[1]。

WAY-270599名称

• 英文名: WAY-270599

WAY-270599生物活性

• 描述: EJMC-1是一种中等强度的TNF-α抑制剂,IC50值为42μM[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 靶点实验:

  TNF-α:42 μM (IC50)

• 参考文献:

  [1]. Deng X, et al. Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors. Front Chem. 2018 Apr 4;6:98.

WAY-270599物理化学性质

• 密度: 1.651±0.06 g/cm3(Predicted)
• 分子式: C₁₇H₁₁ClN₂O₄S
• 分子量: 374.8
• InChIKey: FQWAQUPLBBOCSP-UHFFFAOYSA-N
• SMILES: O=C1Nc2ccc(S(=O)(=O)Nc3ccc(O)c(Cl)c3)c3cccc1c23

WAY-270599靶点实验

查看更多实验

实验名称：Inhibition of recombinant human TNFalpha binding to TNF receptor 1-ECD at 100 uM by s... 来源：ChEMBL 靶标：Tumor necrosis factor External Id：CHEMBL3361501

实验名称：Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-k... 来源：ChEMBL 靶标：Tumor necrosis factor External Id：CHEMBL3361502

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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WAY-270599英文别名

• N-(3-chloro-4-hydroxyphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide