Cyclapolin 9

• 常用名: Cyclapolin 9
• 英文名: Cyclapolin 9
• CAS号: 40533-25-3
• 分子量: 307.20600
• 密度: N/A
• 沸点: N/A
• 分子式: C₉H₄F₃N₃O₄S
• 熔点: N/A
• 闪点: N/A

Cyclapolin 9用途

Cyclapolin 9 是一种有效的,选择性的和 ATP 竞争性 polo-like kinase 1 (PLK1) 抑制剂,IC50 为 500 nM,对其他激酶没有活性。

Cyclapolin 9名称

• 中文名: 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide
• 英文名: Cyclapolin 9

Cyclapolin 9生物活性

• 描述: Cyclapolin 9 是一种有效的,选择性的和 ATP 竞争性 polo-like kinase 1 (PLK1) 抑制剂,IC50 为 500 nM,对其他激酶没有活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> Polo样激酶(PLK)
• 靶点实验:

  PLK1:500 nM (IC50)

• 体外研究: 环载脂蛋白9(3μM)可降低电场刺激(EFS)诱导的前列腺条收缩。环载脂蛋白9可抑制前列腺α1肾上腺素能平滑肌收缩[1]。
• 参考文献:

  [1]. Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734.

  [2]. Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17.

Cyclapolin 9物理化学性质

• 分子式: C₉H₄F₃N₃O₄S
• 分子量: 307.20600
• 精确质量: 306.98700
• PSA: 142.61000
• LogP: 3.57920
• InChIKey: FHFLXKUKCSDMLD-UHFFFAOYSA-N
• SMILES: NC(=O)c1sc2c([N+](=O)[O-])cc(C(F)(F)F)cc2[n+]1[O-]
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

Cyclapolin 9安全信息

• 海关编码: 2934999090

Cyclapolin 9海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Cyclapolin 9靶点实验

查看更多实验

实验名称：Inhibition of CSK at 100 uM relative to control 来源：ChEMBL 靶标：Tyrosine-protein kinase CSK External Id：CHEMBL1228789

实验名称：Inhibition of Chk2 at 100 uM relative to control 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk2 External Id：CHEMBL1228788

实验名称：Inhibition of Chk1 at 100 uM relative to control 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL1228787

实验名称：Inhibition of CDK2/E at 100 uM relative to control 来源：ChEMBL 靶标：G1/S-specific cyclin-E1 External Id：CHEMBL1228786

实验名称：Inhibition of c-RAF at 100 uM relative to control 来源：ChEMBL 靶标：RAF proto-oncogene serine/threonine-protein kinase External Id：CHEMBL1228785

实验名称：Inhibition of MKK6 at 100 uM relative to control 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 6 External Id：CHEMBL1228797

实验名称：Inhibition of MEK1 at 100 uM relative to control 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 1 External Id：CHEMBL1228796

实验名称：Inhibition of MAPKAP-K2 at 100 uM relative to control 来源：ChEMBL 靶标：MAP kinase-activated protein kinase 2 External Id：CHEMBL1228795

实验名称：Inhibition of JNK2alpha2 at 100 uM relative to control 来源：ChEMBL 靶标：Mitogen-activated protein kinase 9 External Id：CHEMBL1228794

实验名称：Inhibition of PLK1 来源：ChEMBL 靶标：Serine/threonine-protein kinase PLK1 External Id：CHEMBL985261

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Cyclapolin 9英文别名

• 5-methylpyridazinecarboxamide 4-oxide
• 5-methyl-pyrazin-2-carboxamide-4-oxide
• 2-carbamoyl-5-methylpyrazine 4-oxide
• Pyrazinecarboxamide,5-methyl-,4-oxide
• 7-nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide
• L-NMMA acetate
• 5-methyl-pyrazine-2-carboxamide-4-oxide
• 2-Carbamoyl-5-methylpyrazin-4-oxid
• 5-methyl-4-oxy-pyrazine-2-carboxylic acid amide
• 2-Carbamoyl-7-nitro-5-trifluormethyl-benzothiazole-N-oxide