A2AR激动剂-1

• 常用名: A2AR激动剂-1
• 英文名: A2AR-agonist-1
• CAS号: 41552-95-8
• 分子量: 410.42600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₂N₆O₄
• 熔点: N/A
• 闪点: N/A

A2AR激动剂-1用途

A2AR-agonist-1是一种有效的 A2AR 和ENT1激动剂, Ki值 分别为 4.39和 3.47。

A2AR激动剂-1名称

• 中文名: A2AR激动剂-1
• 英文名: N6-[(1H-indole-3-yl)ethyl]adenosine

A2AR激动剂-1生物活性

• 描述: A2AR-agonist-1是一种有效的 A2AR 和ENT1激动剂, Ki值 分别为 4.39和 3.47。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-1400.

  [2]. Lin Yun-Lian, et al. Dual-action compounds targeting adenosine A2A receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases. From PCT Int. Appl. (2012), WO 2012064340 A1 20120518.

  [3]. Chen, Chih-Cheng, et al. Methods and compositions for treating pain. From PCT Int. Appl. (2013), WO 2013120078 A1 20130815.

A2AR激动剂-1物理化学性质

• 分子式: C₂₀H₂₂N₆O₄
• 分子量: 410.42600
• 精确质量: 410.17000
• PSA: 141.34000
• LogP: 0.64670
• InChIKey: QGCNEMXXKWZPHR-WVSUBDOOSA-N
• SMILES: OCC1OC(n2cnc3c(NCCc4c[nH]c5ccccc45)ncnc32)C(O)C1O
• 储存条件: 2-8℃

A2AR激动剂-1英文别名

• N6-(4-hydroxybenzyl)adenosine
• N6-(2-(3-indolyl)ethyl)adenosine
• N6-[2-(indol-3-yl)ethyl]adenosine
• (2R,3S,4R,5R)-2-Hydroxymethyl-5-{6-[2-(1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furan-3,4-diol
• 6-[2-(3-Indolyl)ethylamino]-9-(β-D-ribofuranosyl)purine
• N6-(2-indol-3-yl-ethyl)-adenosine
• A2AR-agonist-1