EGFR/HER2/CDK9-IN-3

• 常用名: EGFR/HER2/CDK9-IN-3
• 英文名: EGFR/HER2/CDK9-IN-3
• CAS号: 422276-47-9
• 分子量: 479.57
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₁N₃O₄S₂
• 熔点: N/A
• 闪点: N/A

EGFR/HER2/CDK9-IN-3用途

EGFR/HER2/CDK9-IN-3(化合物10)是EGFR/HER2/CDK9的有效抑制剂,IC50分别为191.08、132.65和113.98 nM。EGFR/HER2/CDK9-IN-3具有显著的抗肿瘤活性[1]。

EGFR/HER2/CDK9-IN-3名称

• 英文名: EGFR/HER2/CDK9-IN-3

EGFR/HER2/CDK9-IN-3生物活性

• 描述: EGFR/HER2/CDK9-IN-3(化合物10)是EGFR/HER2/CDK9的有效抑制剂,IC50分别为191.08、132.65和113.98 nM。EGFR/HER2/CDK9-IN-3具有显著的抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 参考文献:

  [1]. El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.

EGFR/HER2/CDK9-IN-3物理化学性质

• 分子式: C₂₄H₂₁N₃O₄S₂
• 分子量: 479.57

EGFR/HER2/CDK9-IN-3靶点实验

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实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：Binding affinity to human CA2 assessed as inhibition constant by stopped-flow CO2 hyd... 来源：ChEMBL 靶标：Carbonic anhydrase 2 External Id：CHEMBL5104285

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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