TIE-2/VEGFR-2 kinase-IN-4

• 常用名: TIE-2/VEGFR-2 kinase-IN-4
• 英文名: TIE-2/VEGFR-2 kinase-IN-4
• CAS号: 433224-29-4
• 分子量: 539.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₁₇F₄N₅O₄
• 熔点: N/A
• 闪点: N/A

TIE-2/VEGFR-2 kinase-IN-4用途

TIE-2/VEGFR-2激酶-IN-4,苯并咪唑,是一种强效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂,IC50值分别为5.2 nM和5.1 nM。TIE-2/VEGFR-2激酶-IN-4可用于血管生成的研究[1]。

TIE-2/VEGFR-2 kinase-IN-4名称

• 英文名: TIE-2/VEGFR-2 kinase-IN-4

TIE-2/VEGFR-2 kinase-IN-4生物活性

• 描述: TIE-2/VEGFR-2激酶-IN-4,苯并咪唑,是一种强效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂,IC50值分别为5.2 nM和5.1 nM。TIE-2/VEGFR-2激酶-IN-4可用于血管生成的研究[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
• 靶点实验:

  Tie2:5.2 mM (IC50)

  VEGFR-2:5.1 nM (IC50)

• 参考文献:

  [1]. Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50(18):4453-70.

TIE-2/VEGFR-2 kinase-IN-4物理化学性质

• 分子式: C₂₆H₁₇F₄N₅O₄
• 分子量: 539.44
• InChIKey: ODKIFGJQIHHLAP-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(Oc2ccc3nc(NC(=O)c4ccco4)[nH]c3c2)cc1)Nc1cc(C(F)(F)F)ccc1F

TIE-2/VEGFR-2 kinase-IN-4靶点实验

查看更多实验

实验名称：Inhibition of GST-tagged human recombinant VEGFR2 expressed in baculovirus 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL895710

实验名称：Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as a... 来源：ChEMBL 靶标：Angiopoietin-1 receptor External Id：CHEMBL895711

实验名称：qHTS Assay for Inhibitors of Sea Pansy Luciferase from the GSK Published Protein Kina... 来源：NCGC 靶标：Renilla-luciferin 2-monooxygenase (EC 1.13.12.5) - sea pansy (Renilla reniformis) (fragment) External Id：RLUC2000

实验名称：Homogeneous Time-Resolved Fluorescence (HTRF) Enzyme Assay from Article 10.1021/jm061... 来源：BindingDB 靶标：N/A External Id：BindingDB_2178_1

实验名称：GSK PKIS2: Screen against O. lienalis microfilariae, single point, at 3.1uM to assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3988182

实验名称：qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase... 来源：NCGC 靶标：Luciferase [Photinus pyralis] External Id：FLUC2000

实验名称：qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen 来源：NCGC 靶标：tyrosine-protein kinase Yes [Homo sapiens] External Id：Yes1-inhibition-p1

实验名称：Inhibition of GST-tagged human recombinant TIE2 expressed in baculovirus 来源：ChEMBL 靶标：Angiopoietin-1 receptor External Id：CHEMBL895709

实验名称：qHTS for small molecule inhibitors of Yes1 kinase: Counter Assay 来源：NCGC 靶标：N/A External Id：Yes1-inhibition-counter

实验名称：qHTS for Inhibitors of binding or entry into cells for Marburg Virus 来源：NCGC 靶标：gene 4 small orf - Marburg virus External Id：VSVM-OFFLINE

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