4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine

• 常用名: 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
• 英文名: 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
• CAS号: 433311-07-0
• 分子量: 387.56500
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₅N₅S₂
• 熔点: N/A
• 闪点: N/A

用途

MI-1抑制Menin-MLL与1.9μM IC50的相互作用[1]。

名称

• 英文名: 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine

生物活性

• 描述: MI-1抑制Menin-MLL与1.9μM IC50的相互作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 参考文献:

  [1]. Vedadi M, et al. Targeting human SET1/MLL family of proteins. Protein Sci. 2017 Apr;26(4):662-676. doi: 10.1002/pro.3129. Epub 2017 Mar 6.

物理化学性质

• 分子式: C₁₉H₂₅N₅S₂
• 分子量: 387.56500
• 精确质量: 387.15500
• PSA: 98.16000
• LogP: 3.01200
• InChIKey: MNSXQGKLDTVOLP-UHFFFAOYSA-N
• SMILES: CC1(C)CN=C(N2CCN(c3ncnc4sc5c(c34)CCCC5)CC2)S1

安全信息

• 危险品运输编码: NONH for all modes of transport

靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. 来源：University of Pittsburgh Molecular Library Screening Center 靶标：N/A External Id：MH081226: Primary HTS for Inhibitors of a Novel Necrotic Cell Death Pathway # Jurkat FADD-/- Model.

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：NMR Spectroscopy Assay from US Patent US8993552: "Compositions and methods for treatm... 来源：BindingDB 靶标：N/A External Id：BindingDB_6769_3

实验名称：Homogeneous Time-Resolve Fluorescence (HTRF) Assay from US Patent US8993552: "Composi... 来源：BindingDB 靶标：N/A External Id：BindingDB_6769_2

实验名称：Confirmed allosteric antagonists of M1 Muscarinic receptor 来源：1043 靶标：Muscarinic acetylcholine receptor M1 External Id：SAID_435034

实验名称：Fluorescence Polarization Assay from US Patent US8993552: "Compositions and methods f... 来源：BindingDB 靶标：N/A External Id：BindingDB_6769_1

实验名称：384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC 来源：University of Pittsburgh Molecular Library Screening Center 靶标：N/A External Id：MH083223 Targeting HIV-1 Nef with Small Molecules

实验名称：Oral bioavailability in CD-1 mouse at 100 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5333020

共19条，当前第1页，共2页

1

2