左旋箭毒碱

• 常用名: 左旋箭毒碱
• 英文名: Curine
• CAS号: 436-05-5
• 分子量: 594.697
• 密度: 1.2±0.1 g/cm3
• 沸点: 706.5±60.0 °C at 760 mmHg
• 分子式: C₃₆H₃₈N₂O₆
• 熔点: 213°; mp 221° in vacuo; mp 161°
• 闪点: 381.1±32.9 °C

左旋箭毒碱用途

(-)-Curine 是一种从白僵菌中提取的,具有口服活性的双苄基异喹啉生物碱。(-)-Curine 在无毒剂量下具有抗炎和镇痛作用,至少部分是由于抑制前列腺素 E2 产生的。

左旋箭毒碱名称

• 中文名: (-)-箭毒素
• 英文名: curine
• 中文别名: L-箭毒碱 | 左旋箭毒碱 | 筒箭毒次鹼

左旋箭毒碱生物活性

• 描述: (-)-Curine 是一种从白僵菌中提取的,具有口服活性的双苄基异喹啉生物碱。(-)-Curine 在无毒剂量下具有抗炎和镇痛作用,至少部分是由于抑制前列腺素 E2 产生的。
• 相关类别:
  研究领域 >> 内分泌
• 靶点实验:

  EP2

• 参考文献:

  [1]. Leite FC, et al. Curine, an alkaloid isolated from Chondrodendron platyphyllum inhibits prostaglandin E2 in experimental models of inflammation and pain. Planta Med. 2014 Aug;80(13):1072-8.

左旋箭毒碱物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 706.5±60.0 °C at 760 mmHg
• 熔点: 213°; mp 221° in vacuo; mp 161°
• 分子式: C₃₆H₃₈N₂O₆
• 分子量: 594.697
• 闪点: 381.1±32.9 °C
• 精确质量: 594.273010
• PSA: 83.86000
• LogP: 4.12
• InChIKey: NGZXDRGWBULKFA-VSGBNLITSA-N
• SMILES: COc1cc2c3cc1Oc1cc(ccc1O)CC1c4c(cc(OC)c(O)c4Oc4ccc(cc4)CC3N(C)CC2)CCN1C
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.620
• 储存条件: 2-8℃

左旋箭毒碱安全信息

• 危害码 (欧洲): T+: Very toxic;
• 风险声明 (欧洲): R26/27/28
• 安全声明 (欧洲): 22-36/37/39-45
• 危险品运输编码: UN 1544
• WGK德国: 3

左旋箭毒碱靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Specificity screen against TRPC6 for compounds that activate transient receptor poten... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_AG_Counter_C6

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Specificity screen against TRPC6 for compounds that inhibit transient receptor potent... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_Inh_Counter_C6

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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左旋箭毒碱英文别名

• Chondodendrine
• 1-Curine
• l-Curine
• Einecs 207-109-4
• (1β)-6,6'-Dimethoxy-2,2'-dimethyltubocuraran-7',12'-diol
• (-)-BEBEERINE
• 1-Bebeerine
• Chonodoendrine (L)
• L-BEBEERINE
• d-bebeerine
• (+-)-chondrodendrine