烟酸占替诺

• 常用名: 烟酸占替诺
• 英文名: Xanthinol Nicotinate
• CAS号: 437-74-1
• 分子量: 434.446
• 密度: N/A
• 沸点: 589.3ºC at 760 mmHg
• 分子式: C₁₉H₂₆N₆O₆
• 熔点: 180-184ºC
• 闪点: 310.2ºC

烟酸占替诺用途

Xanthinol Nicotinate (Xanthinol Niacinate) 是一种血管扩张剂,可以直接作用于小动脉和毛细血管的平滑肌。Xanthinol Nicotinate 可以扩大血管,改善血液流变学并降低外周血管阻力。

烟酸占替诺名称

• 中文名: 烟酸占替诺
• 英文名: 7-[2-hydroxy-3-[2-hydroxyethyl(methyl)amino]propyl]-1,3-dimethylpurine-2,6-dione,pyridine-3-carboxylic acid
• 中文别名: 7-[2-羟基-3-(2-羟乙基-甲胺基)丙基]苯碱烟酸盐 | 尼可占替诺 | 脑康 | 7-[2-羟基-3-(2-羟乙基-甲胺基)丙基]-1,3-二甲基-嘌呤-2,6-二酮烟酸盐 | 7-[3-[(2-羟乙基)甲氨基]-2-羟丙基]茶碱尼古丁酸酯

烟酸占替诺生物活性

• 描述: Xanthinol Nicotinate (Xanthinol Niacinate) 是一种血管扩张剂,可以直接作用于小动脉和毛细血管的平滑肌。Xanthinol Nicotinate 可以扩大血管,改善血液流变学并降低外周血管阻力。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体外研究: 烟酸黄原醇(烟酸黄原醇；2.76-276μM；24小时)以剂量依赖性方式抑制HUASMC增殖[2]。烟酸黄原醇(2.76-276μM；24小时)剂量依赖性地降低HUASMCs细胞膜上PDGFR-mRNA和PDGFR-β的水平[2]。细胞增殖试验[2]细胞系：人脐动脉平滑肌细胞(HUASMC)浓度：2.76、27.6或276μM培养时间：24小时结果：抑制HUASMC增殖呈剂量依赖性。Western Blot分析[2]细胞株：huascm浓度：2.76、27.6或276μM孵育时间：24小时结果：剂量依赖性降低huascm细胞膜上PDGFR mRNA和PDGFR-β水平。
• 体内研究: 烟酸黄原醇(烟酸黄原醇；75mg/kg；IP)能快速、短暂地改变肿瘤pO2,最大pO2值在烟酸黄原醇给药后10～30min内获得[1]。烟酸黄原醇能够在肿瘤复氧期间应用10gy的X射线对肿瘤进行放射增敏(放射反应增强1.4)[1]。动物模型：5周龄雄性NMRI小鼠[1]剂量：75mg/kg给药：IP结果：XN给药后10～30min,肿瘤pO2迅速、短暂改变,pO2值最大。
• 参考文献:

  [1]. Segers J, et al. Use of Xanthinol Nicotinate as a co-treatment for radio- and chemo-therapy in experimental tumors. Int J Cancer. 2010 Jan 15;126(2):583-8.

  [2]. Bai X, et al. Inhibited proliferation of human umbilical artery smooth muscle cells by xanthinol nicotinate. Med Biol Eng Comput. 2016 Jun;54(6):891-8.

烟酸占替诺物理化学性质

• 沸点: 589.3ºC at 760 mmHg
• 熔点: 180-184ºC
• 分子式: C₁₉H₂₆N₆O₆
• 分子量: 434.446
• 闪点: 310.2ºC
• 精确质量: 434.191376
• PSA: 155.71000
• InChIKey: GEPMAHVDJHFBJI-UHFFFAOYSA-N
• SMILES: CN(CCO)CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C.O=C(O)c1cccnc1
• 外观性状: 白色结晶粉末
• 蒸汽压: 9.89E-15mmHg at 25°C
• 储存条件: -20℃

烟酸占替诺MSDS

烟酸占替诺MSDS英文版

烟酸占替诺毒性和生态

烟酸占替诺安全信息

• WGK德国: 2
• RTECS号: QT1500000
• 海关编码: 2933990090

烟酸占替诺海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

烟酸占替诺靶点实验

查看更多实验

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实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

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烟酸占替诺英文别名

• Nicotinic acid - 7-{2-hydroxy-3-[(2-hydroxyethyl)(methyl)amino]propyl}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (1:1)
• 7-[3-[N-(2-Hydroxyethyl)amino]-2-hydroxypropyl]theophylline nicotinate
• Teonicol
• Xanthinol Niacinate
• Xantinol nicotinate
• SK 331-A
• Angioamin
• Xantinol Niacinate
• Complamex
• EINECS 207-115-7
• Xanthinolnicotinat
• Sadamine
• 3-Pyridinecarboxylic acid, compd. with 3,7-dihydro-7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-1,3-dimethyl-1H-purine-2,6-dione (1:1)
• Landrina
• 3-Pyridinecarboxylic acid, compd. with 3,7-dihydro-7-(2-hydroxy-3-((2-hydroxyethyl)methylamino)propyl)-1,3-dimethyl-1H-purine-2,6-dione (1:1)
• Xanthinol nicotinate
• Contamex
• MFCD00058342
• Xavin
• Stenalgil
• 3-Pyridinecarboxylic acid compd with 3,7-dihydro-7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-1,3-dimethyl-1H-purine-2,6-dione (1:1)
• 7-[2-Hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]theophylline compd with nicotinic acid
• Complamin
• pyridine-3-carboxylic acid - 7-{2-hydroxy-3-[(2-hydroxyethyl)(methyl)amino]propyl}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (1:1)