Besifovir Dipivoxil maleate

• 常用名: Besifovir Dipivoxil maleate
• 英文名: Besifovir Dipivoxil maleate
• CAS号: 441785-26-8
• 分子量: 527.50800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₈N₅O₁₂P
• 熔点: N/A
• 闪点: N/A

Besifovir Dipivoxil maleate用途

Besifovir Dipivoxil maleate (LB80380 maleate) 是 LB80317 的口服前药。Besifovir Dipivoxil maleate (LB80380 maleate) 对野生型和 Lamivudine 耐药型的慢性乙型肝炎 (CHB) 患者的乙型肝炎病毒 (HBV) DNA 抑制均有效。

Besifovir Dipivoxil maleate名称

• 英文名: lb-80380

Besifovir Dipivoxil maleate生物活性

• 描述: Besifovir Dipivoxil maleate (LB80380 maleate) 是 LB80317 的口服前药。Besifovir Dipivoxil maleate (LB80380 maleate) 对野生型和 Lamivudine 耐药型的慢性乙型肝炎 (CHB) 患者的乙型肝炎病毒 (HBV) DNA 抑制均有效。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> HBV
• 参考文献:

  [1]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.

  [2]. Lai CL, et al. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Gut. 2014 Jun;63(6):996-1004.

Besifovir Dipivoxil maleate物理化学性质

• 分子式: C₂₆H₃₈N₅O₁₂P
• 分子量: 527.50800
• 精确质量: 527.21400
• PSA: 176.79000
• LogP: 3.81630

Besifovir Dipivoxil maleate英文别名

• ({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methylphosphonic acid dipivoxyl
• 2,2-Dimethyl-propionic acid [1-(2-amino-purin-9-ylmethyl)-cyclopropoxymethyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester
• 3-[({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]-8,8-dimethyl-3,7-dioxo-2,4,6-trioxa-3λ5-phosphanon-1-yl-pivalate
• 9-[1-(phosphonomethoxycyclopropyl)methyl]-6-deoxyguanine
• 3-[({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]-8,8-dimethyl-3,7-dioxo-2,4,6-trioxa-3λ5-phosphanon-1-yl pivalate