p38-αMAPK-IN-1

• 常用名: p38-αMAPK-IN-1
• 英文名: p38-α MAPK-IN-1
• CAS号: 443913-15-3
• 分子量: 477.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₅N₅O₃
• 熔点: N/A
• 闪点: N/A

p38-αMAPK-IN-1用途

p38-α MAPK-IN-1 是 MAPK14 (p38-α) 抑制剂,在 EFC 和 HTRF 实验中,IC50 值分别为 2300 nM 和 5500 nM。

p38-αMAPK-IN-1名称

• 中文名: p38-αMAPK-IN-1
• 英文名: p38-α MAPK-IN-1

p38-αMAPK-IN-1生物活性

• 描述: p38-α MAPK-IN-1 是 MAPK14 (p38-α) 抑制剂,在 EFC 和 HTRF 实验中,IC50 值分别为 2300 nM 和 5500 nM。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 其他
• 靶点实验:

  IC50: 2300 nM (p38-α, in EFC assay), 5500 nM (p38-α, in HTRF assay)[1]

• 体外研究: p38-αMAPK-IN-1(化合物12)是MAPK14(p38-α)的抑制剂,EFC置换试验中IC50为2300 nM,HTRF试验中IC50为5500 nM [1]。
• 参考文献:

  [1]. Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53(1):357-67.

p38-αMAPK-IN-1物理化学性质

• 分子式: C₂₇H₃₅N₅O₃
• 分子量: 477.6
• InChIKey: FRZNJFWQVYAVCE-UHFFFAOYSA-N
• SMILES: Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)cc2)cc1
• 储存条件: 2-8℃

p38-αMAPK-IN-1靶点实验

查看更多实验

实验名称：Inhibition Assay from Article 10.1021/cb300128b: "Targeting GSK3 from Ustilago maydis... 来源：BindingDB 靶标：N/A External Id：BindingDB_5635_1

实验名称：Inhibition of JNK2 active form by HTRF assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 9 External Id：CHEMBL1050684

实验名称：Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 11 External Id：CHEMBL807825

实验名称：Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluo... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 11 External Id：CHEMBL732617

实验名称：Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by H... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL1050682

实验名称：Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 9 External Id：CHEMBL1050683

实验名称：Inhibition of Ustilago maydis GSK-3beta using Ser/Thr 6 peptide as substrate preincub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4736842

实验名称：Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL1050681

实验名称：Inhibition of human GSK-3beta using Ser/Thr 6 peptide as substrate preincubated for 6... 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL4736841

实验名称：Rate of dissociation from Mitogen-activated protein kinase p38 alpha 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL733329

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