Brincidofovir

• 常用名: Brincidofovir
• 英文名: Brincidofovir
• CAS号: 444805-28-1
• 分子量: 561.69100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₅₂N₃O₇P
• 熔点: N/A
• 闪点: N/A

Brincidofovir用途

CMX001 (Brincidofovir; HDP-CDV) 是一种具有口服活性的Cidofovir (CDV) 亲脂形式,对某些疱疹病毒,腺病毒和正痘病毒,比CDV具有更强的体内外活性。

Brincidofovir名称

• 中文名: Brincidofovir
• 英文名: [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid

Brincidofovir生物活性

• 描述: CMX001 (Brincidofovir; HDP-CDV) 是一种具有口服活性的Cidofovir (CDV) 亲脂形式,对某些疱疹病毒,腺病毒和正痘病毒,比CDV具有更强的体内外活性。
• 相关类别:
  信号通路 >> 抗感染 >> CMV
  研究领域 >> 感染
• 参考文献:

  [1]. Parker S, et al. Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model. Antiviral Res. 2008 Jan;77(1):39-49.

  [2]. Quenelle DC, et al. Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distributionstudies. J Infect Dis. 2010 Nov 15;202(10):1492-9.

  [3]. Gosert R, et al. CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes. Antimicrob Agents Chemother. 2011 May;55(5):2129-36.

  [4]. Marty FM, et al. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation. N Engl J Med. 2013 Sep 26;369(13):1227-36.

Brincidofovir物理化学性质

• 分子式: C₂₇H₅₂N₃O₇P
• 分子量: 561.69100
• 精确质量: 561.35400
• PSA: 156.93000
• LogP: 5.59290
• InChIKey: WXJFKKQWPMNTIM-VWLOTQADSA-N
• SMILES: CCCCCCCCCCCCCCCCOCCCOP(=O)(O)COC(CO)Cn1ccc(N)nc1=O
• 储存条件: -20°C，密闭，干燥

Brincidofovir靶点实验

查看更多实验

实验名称：Antiviral activity against Vaccinia virus infected in human HFF cells 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL5349951

实验名称：Metabolic stability in rhesus monkey liver S9 fraction assessed as compound remaining... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1776363

实验名称：Metabolic stability in human liver S9 fraction assessed as compound remaining at 1 uM... 来源：ChEMBL 靶标：Liver External Id：CHEMBL1776362

实验名称：Selectivity index, ratio of CC50 for human HFF cells to EC50 for Cowpox virus (Bright... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1777581

实验名称：Antiviral activity against Vaccinia virus Copenhagen infected in human HFF cells afte... 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL1777580

实验名称：Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells af... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1777583

实验名称：Cytotoxicity against human HFF cells assessed as reduction in cell viability after 7 ... 来源：ChEMBL 靶标：HFF External Id：CHEMBL1777582

实验名称：Cytotoxicity against african green monkey BSC1 cells after 2 to 4 hrs by MTS assay 来源：ChEMBL 靶标：BSC-1 External Id：CHEMBL1777585

实验名称：Selectivity index, ratio of CC50 for african green monkey BSC1 cells to EC50 for Ectr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1777584

实验名称：Antiviral activity against Ectromelia virus Moscow infected in african green monkey B... 来源：ChEMBL 靶标：Ectromelia virus Moscow External Id：CHEMBL1777586

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Brincidofovir英文别名

• HDP-CDV
• Hexadecyloxypropyl-cidofovir
• HDP-HPMPC
• Brincidofovir
• 1-O-hexadecylpropanediol-CDV
• CMX001
• HDP-Cidofovir
• CMX-001