Grayanotoxin II

• 常用名: Grayanotoxin II
• 英文名: Grayanotoxin II
• CAS号: 4678-44-8
• 分子量: 352.46500
• 密度: 1.3g/cm3
• 沸点: 522.9ºC at 760 mmHg
• 分子式: C₂₀H₃₂O₅
• 熔点: N/A
• 闪点: 237.9ºC

Grayanotoxin II用途

灰烷毒素II是一种强效镇痛剂,是一种二萜类化合物。灰毒素II显示出显著的镇痛活性[1]。

Grayanotoxin II名称

• 英文名: (3β,6β,14R)-Grayanotox-10-ene-3,5,6,14,16-pentol

Grayanotoxin II生物活性

• 描述: 灰烷毒素II是一种强效镇痛剂,是一种二萜类化合物。灰毒素II显示出显著的镇痛活性[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 灰毒毒素II(5 mg/kg；腹腔注射)在乙酸诱导的小鼠扭体试验中显示出显着的镇痛活性[1]。 动物模型：昆明小鼠(醋酸致扭体试验)[1]剂量：5mg/kg给药：I.p.结果：小鼠表现出显著的镇痛活性。
• 参考文献:

  [1]. Chang-Shan Niu, et al. Analgesic diterpenoids from the twigs of Pieris formosa. Tetrahedron. 2016, 72(1): 44-49.

Grayanotoxin II物理化学性质

• 密度: 1.3g/cm3
• 沸点: 522.9ºC at 760 mmHg
• 分子式: C₂₀H₃₂O₅
• 分子量: 352.46500
• 闪点: 237.9ºC
• 精确质量: 352.22500
• PSA: 101.15000
• LogP: 0.97350
• InChIKey: KEOQZUCOGXIEQR-UHFFFAOYSA-N
• SMILES: C=C1C2CCC3C(O)C2(CC(O)C2(O)C1CC(O)C2(C)C)CC3(C)O
• 折射率: 1.61

Grayanotoxin II安全信息

• 危险品运输编码: UN 3172
• 危险类别: 6.1(a)

Grayanotoxin II靶点实验

查看更多实验

实验名称：Cytotoxicity against mouse RAW264.7 cells at 200 uM measured in presence of LPS by MT... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4136754

实验名称：Antinociceptive activity in mouse as reduction in acetic acid-induced writhes at 5 mg... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4417373

实验名称：Cytotoxicity against mouse RAW264.7 cells at 200 uM measured in absence of LPS by MTT... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4136753

实验名称：Antinociceptive activity in Kunming mouse model of acute pain assessed as inhibition ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3769238

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4136750

实验名称：Analgesic activity in Kunming mouse model of acetic-acid-induced writhing assessed as... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4340321

实验名称：Antifeedant activity in gypsy moth ten third-instar larvae at 15 ug/ml relative to co... 来源：ChEMBL 靶标：Lymantria dispar External Id：CHEMBL1025898

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Grayanotoxin II英文别名

• 7-(prop-2-in-1-yloxy)-1-benzopyran-2-one
• 7-Propargyloxy-cumarin [German]
• 2H-1-Benzopyran-2-one,7-(2-propynyloxy)
• (7R)-1,1,8-Trimethyl-4-methylen-(3ac,4at)-dodecahydro-7r,9ac-methano-cyclopenta[b]heptalen-2t,8c,11t,11at,12anti-pentaol
• Grayanatoxin-II
• Grayanotoxin-II
• (3aR)-2c.8t.11c.11ac.12anti-Pentahydroxy-1.1.8c-trimethyl-4-methylen-(3arH.4acH)-tetradecahydro-7t.9at-methano-cyclopenta[b]heptalen
• Andromedenol
• (7-coumaryloxy)methylacetylene
• (7R)-1,1,8-trimethyl-4-methylene-(3ac,4at)-dodecahydro-7r,9ac-methano-cyclopenta[b]heptalene-2t,8c,11t,11at,12anti-pentaol
• (7-propargyloxy)coumarin
• 7-Propargyloxy-cumarin
• 7-(2-Propynyloxy)-2H-1-benzopyran-2-one
• 7-(prop-2-yn-1-yloxy)-2H-chromen-2-one