24-亚甲基环木菠萝烷醇阿魏酸酯

• 常用名: 24-亚甲基环木菠萝烷醇阿魏酸酯
• 英文名: 24-Methylene cycloartanyl ferulate
• CAS号: 469-36-3
• 分子量: 616.913
• 密度: 1.1±0.1 g/cm3
• 沸点: 668.4±40.0 °C at 760 mmHg
• 分子式: C₄₁H₆₀O₄
• 熔点: N/A
• 闪点: 193.5±20.8 °C

24-亚甲基环木菠萝烷醇阿魏酸酯用途

阿魏酸24-亚甲基环沙坦酯是一种γ-谷维素化合物。阿魏酸24-亚甲基环沙坦促进人乳腺癌细胞中parvinβ的表达。24-亚甲基-阿魏酸环沙坦酯是一种潜在的ATP竞争性Akt1抑制剂(EC50=33.3μM)[1]。

24-亚甲基环木菠萝烷醇阿魏酸酯名称

• 中文名: gamma-谷维素
• 英文名: oryzanol
• 中文别名: 伽马谷维素 | γ-谷维素

24-亚甲基环木菠萝烷醇阿魏酸酯生物活性

• 描述: 阿魏酸24-亚甲基环沙坦酯是一种γ-谷维素化合物。阿魏酸24-亚甲基环沙坦促进人乳腺癌细胞中parvinβ的表达。24-亚甲基-阿魏酸环沙坦酯是一种潜在的ATP竞争性Akt1抑制剂(EC50=33.3μM)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
• 靶点实验:

  Akt1:33.3 μM (EC50)

• 参考文献:

  [1]. Heon Woong Kim, et al. 24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells. Biochem Biophys Res Commun. 2015 Dec 25;468(4):574-9.

24-亚甲基环木菠萝烷醇阿魏酸酯物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 668.4±40.0 °C at 760 mmHg
• 分子式: C₄₁H₆₀O₄
• 分子量: 616.913
• 闪点: 193.5±20.8 °C
• 精确质量: 616.449158
• PSA: 55.76000
• LogP: 13.20
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.564

24-亚甲基环木菠萝烷醇阿魏酸酯靶点实验

查看更多实验

实验名称：Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells a... 来源：ChEMBL 靶标：Human gammaherpesvirus 4 External Id：CHEMBL905095

实验名称：Cell viability of Raji cells at 320 nM 来源：ChEMBL 靶标：Raji External Id：CHEMBL905096

实验名称：Scavenging activity against NO generation in human Chang liver cells assessed as inhi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL905097

实验名称：Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL979214

实验名称：Antiviral activity against HIV1 Reverse transcriptase activity 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL1786436

实验名称：Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV... 来源：ChEMBL 靶标：Human gammaherpesvirus 4 External Id：CHEMBL905091

实验名称：Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV... 来源：ChEMBL 靶标：Human gammaherpesvirus 4 External Id：CHEMBL905092

实验名称：Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV... 来源：ChEMBL 靶标：Human gammaherpesvirus 4 External Id：CHEMBL905093

实验名称：Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV... 来源：ChEMBL 靶标：Human gammaherpesvirus 4 External Id：CHEMBL905094

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24-亚甲基环木菠萝烷醇阿魏酸酯英文别名

• 24-Methylenecycloartanyl Ferulate
• 3-O-feruloylquinic acid
• Oryzanol C
• 3-Feruloylchinasaeure
• 3-feruloylquinic acid
• 3-O-ferulyl-24-methylenecycloartanol
• 5-O-feruloyl quinic acid
• 24-methylenecycloartanol ferulate
• 24-methylcycloartanyl ferulate
• 24-methylene cycloartanyl ferulate
• (3β,9β)-24-Methylene-9,19-cyclolanostan-3-yl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
• (3β,9β)-24-methylidene-9,19-cyclolanostan-3-yl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
• 24-methylenecycloartanol trans-ferulate
• 5-feruloylquinic acid