AZM475271

• 常用名: AZM475271
• 英文名: AZM475271
• CAS号: 476159-98-5
• 分子量: 442.93800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₇ClN₄O₃
• 熔点: N/A
• 闪点: N/A

AZM475271用途

AZM475271是Src激酶高效选择性抑制剂,IC50值为5nM,对Flt3、KDR和Tie-2抑制剂弱(IC50>10uM)。

AZM475271名称

• 中文名: AZM475271
• 英文名: N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

AZM475271生物活性

• 描述: AZM475271是Src激酶高效选择性抑制剂,IC50值为5nM,对Flt3、KDR和Tie-2抑制剂弱(IC50>10uM)。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> SRC
  研究领域 >> 癌症
• 参考文献:

  [1]. Plé PA, et al. Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. J Med Chem. 2004 Feb 12;47(4):871-87.

  [2]. Yezhelyev MV, et al. Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin Cancer Res. 2004 Dec 1;10(23):8028-36.

AZM475271物理化学性质

• 分子式: C₂₃H₂₇ClN₄O₃
• 分子量: 442.93800
• 精确质量: 442.17700
• PSA: 68.74000
• LogP: 4.77550
• InChIKey: WPOXAFXHRJYEIC-UHFFFAOYSA-N
• SMILES: COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1
• 储存条件: 2-8℃

AZM475271靶点实验

查看更多实验

实验名称：Bioavailability in male dog 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL856631

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Antiproliferative activity against p53+/+ human HCT116 cells after 72 hrs by CellTite... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4412239

实验名称：Antiproliferative activity against p53-/- human HCT116 cells after 72 hrs by CellTite... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4412240

实验名称：Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter 96 aque... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4412241

实验名称：Clearance in male dog 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL856627

实验名称：Antiproliferative activity against human A549 cells after 72 hrs by CellTiter 96 aque... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4412242

实验名称：Antiproliferative activity against human NHDF cells after 72 hrs by CellTiter 96 aque... 来源：ChEMBL 靶标：NHDF External Id：CHEMBL4412243

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Inhibition of Lyn B (unknown origin) at 0.5 uM preincubated for 10 mins followed by s... 来源：ChEMBL 靶标：Tyrosine-protein kinase Lyn External Id：CHEMBL4412229

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AZM475271英文别名

• Methoxy Aniline 7
• AZM475271