TIE-2/VEGFR-2 kinase-IN-2

• 常用名: TIE-2/VEGFR-2 kinase-IN-2
• 英文名: TIE-2/VEGFR-2 kinase-IN-2
• CAS号: 501693-48-7
• 分子量: 431.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₃F₄N₅O₂
• 熔点: N/A
• 闪点: N/A

TIE-2/VEGFR-2 kinase-IN-2用途

TIE-2/VEGFR-2激酶-IN-2是一种有效的双重VEGFR2和TIE-2抑制剂,pIC50值分别为8.61和8.56[1]。TIE-2/VEGFR-2激酶-IN-2是一种抗血管生成剂,可用于癌症研究[2]。

TIE-2/VEGFR-2 kinase-IN-2名称

• 英文名: TIE-2/VEGFR-2 kinase-IN-2

TIE-2/VEGFR-2 kinase-IN-2生物活性

• 描述: TIE-2/VEGFR-2激酶-IN-2是一种有效的双重VEGFR2和TIE-2抑制剂,pIC50值分别为8.61和8.56[1]。TIE-2/VEGFR-2激酶-IN-2是一种抗血管生成剂,可用于癌症研究[2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
• 靶点实验:

  VEGFR-2

  Tie-2

• 参考文献:

  [1]. Yasushi Miyazaki, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8.

TIE-2/VEGFR-2 kinase-IN-2物理化学性质

• 分子式: C₂₀H₁₃F₄N₅O₂
• 分子量: 431.34
• InChIKey: KNDPXYAMINMLED-UHFFFAOYSA-N
• SMILES: Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12

TIE-2/VEGFR-2 kinase-IN-2靶点实验

查看更多实验

实验名称：GSK_PKIS: KIT (T670I mutant) mean inhibition at 1 uM [Nanosyn] 来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit External Id：CHEMBL1962129

实验名称：GSK_PKIS: KIT (T670I mutant) mean inhibition at 0.1 uM [Nanosyn] 来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit External Id：CHEMBL1962128

实验名称：GSK_PKIS: KIT (V560G mutant) mean inhibition at 1 uM [Nanosyn] 来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit External Id：CHEMBL1962131

实验名称：GSK_PKIS: KIT (V560G mutant) mean inhibition at 0.1 uM [Nanosyn] 来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit External Id：CHEMBL1962130

实验名称：GSK_PKIS: LCK mean inhibition at 1 uM [Nanosyn] 来源：ChEMBL 靶标：Tyrosine-protein kinase Lck External Id：CHEMBL1962133

实验名称：GSK_PKIS: LCK mean inhibition at 0.1 uM [Nanosyn] 来源：ChEMBL 靶标：Tyrosine-protein kinase Lck External Id：CHEMBL1962132

实验名称：GSK_PKIS: LTK mean inhibition at 1 uM [Nanosyn] 来源：ChEMBL 靶标：Leukocyte tyrosine kinase receptor External Id：CHEMBL1962135

实验名称：GSK_PKIS: LTK mean inhibition at 0.1 uM [Nanosyn] 来源：ChEMBL 靶标：Leukocyte tyrosine kinase receptor External Id：CHEMBL1962134

实验名称：GSK_PKIS: JAK3 mean inhibition at 1 uM [Nanosyn] 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL1962121

实验名称：GSK_PKIS: JAK3 mean inhibition at 0.1 uM [Nanosyn] 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL1962120

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