卤米松

• 常用名: 卤米松
• 英文名: Halometasone
• CAS号: 50629-82-8
• 分子量: 444.897
• 密度: 1.4±0.1 g/cm3
• 沸点: 600.5±55.0 °C at 760 mmHg
• 分子式: C₂₂H₂₇ClF₂O₅
• 熔点: 125-130 °C(lit.)
• 闪点: 317.0±31.5 °C

卤米松用途

【用途一】
局部用肾上腺皮质激素类药物，有显著且快速的抗炎、抗过敏、抗瘙痒、抗渗出及抗增生的作用。适用于湿疹性皮肤病及各类轻度湿疹性和亚急性皮炎。

卤米松名称

• 中文名: 卤米松
• 英文名: Halometasone
• 中文别名: (6Α,11Β,16Α)-2-氯-6,9-二氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮 | 卤甲松

卤米松物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 600.5±55.0 °C at 760 mmHg
• 熔点: 125-130 °C(lit.)
• 分子式: C₂₂H₂₇ClF₂O₅
• 分子量: 444.897
• 闪点: 317.0±31.5 °C
• 精确质量: 444.151520
• PSA: 94.83000
• LogP: 2.33
• InChIKey: GGXMRPUKBWXVHE-MIHLVHIWSA-N
• SMILES: CC1CC2C3CC(F)C4=CC(=O)C(Cl)=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO
• 蒸汽压: 0.0±3.9 mmHg at 25°C
• 折射率: 1.586
• 储存条件: 室温
• 分子结构:

  1、 摩尔折射率：104.93

  2、 摩尔体积（cm³/mol）：312.8

  3、 等张比容（90.2K）：854.6

  4、 表面张力（dyne/cm）：55.6

  5、 极化率（10-24cm3）：41.60

卤米松安全信息

• 危害码 (欧洲): Xn
• 安全声明 (欧洲): S22-S24/25
• WGK德国: 3

卤米松制备

化合物(Ⅰ)先和氯气反应，对1、2位双键进行加成，再在吡啶作用下，脱去氯化氢，在1、2位重新形成双键；然后水解，得到卤米松。

卤米松靶点实验

查看更多实验

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291800

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 来源：NCGC 靶标：eyes absent homolog 2 isoform a [Homo sapiens] External Id：EYA2477

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Primary cell-based high-throughput screening for identification of compounds that all... 来源：Johns Hopkins Ion Channel Center 靶标：MAS-related GPR member X1 [Homo sapiens] External Id：JHICC_MrgX1_AlloAgonist_Primary

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

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卤米松英文别名

• 2-Chloro-6a,9-difluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione
• 2-Chloro-6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• MFCD00866091
• (6a,11b,16a)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 2-Chlor-6α,9-difluor-11β,17,21-trihydroxy-16α-methyl-1,4-pregnadien-3,20-dion
• Halometasone
• (6α,11β,16α)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• C 48401-Ba
• EINECS 256-664-9
• (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• 2-CHLOROFLUMETHASONE
• Sicorten