9-hydroxyellipticine

• 常用名: 9-hydroxyellipticine
• 英文名: 9-hydroxyellipticine
• CAS号: 51131-85-2
• 分子量: 262.30600
• 密度: 1.349g/cm3
• 沸点: 557.7ºC at 760mmHg
• 分子式: C₁₇H₁₄N₂O
• 熔点: N/A
• 闪点: 291.1ºC

9-hydroxyellipticine用途

9-hydroxyellipticine, also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines.

9-hydroxyellipticine名称

• 英文名: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol

9-hydroxyellipticine物理化学性质

• 密度: 1.349g/cm3
• 沸点: 557.7ºC at 760mmHg
• 分子式: C₁₇H₁₄N₂O
• 分子量: 262.30600
• 闪点: 291.1ºC
• 精确质量: 262.11100
• PSA: 48.91000
• LogP: 4.19170
• InChIKey: QZTWUDDGLIDXSE-UHFFFAOYSA-N
• SMILES: Cc1c2ccncc2c(C)c2c1[nH]c1ccc(O)cc12

9-hydroxyellipticine毒性和生态

9-hydroxyellipticine靶点实验

查看更多实验

实验名称：Cytotoxicity against H 358 human lung cancer cell line 来源：ChEMBL 靶标：NCI-H358 External Id：CHEMBL871939

实验名称：The effective dose against L1210 cell growth 来源：ChEMBL 靶标：L1210 External Id：CHEMBL885248

实验名称：The effect on oxygen uptake in the presence of MPO-H2O2 at pH 7.8 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722952

实验名称：The effect on oxygen uptake in the presence of MPO-H2O2 at pH 6.0 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722951

实验名称：Cytotoxicity against H 460 human lung cancer cell line 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL880109

实验名称：The effect on oxygen uptake in the presence of MPO-H2O2 at pH 6.8 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722954

实验名称：The effect on oxygen uptake in the presence of MPO-H2O2 at pH 8.3 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722953

实验名称：The effect on oxygen uptake in the presence of MPO-H2O2 without the compound at pH 6.... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL879907

实验名称：DNA binding dissociation constant as KD 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL635338

实验名称：The effect on oxygen uptake in the presence of MPO-H2O2 at pH 7.4 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722955

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9-hydroxyellipticine英文别名

• ELLIPTICINE,9-HYDROXY
• 9-Hydroxyellipticin
• 9-Hydroxyellipticine
• EINECS 257-000-0
• 9-hydroxyelipticine
• IGIG 929
• Hydroxyellipticine