9-hydroxyellipticine

更新时间：2024-01-02 11:18:23

9-hydroxyellipticine结构式	常用名	9-hydroxyellipticine	英文名	9-hydroxyellipticine
	CAS号	51131-85-2	分子量	262.30600
	密度	1.349g/cm3	沸点	557.7ºC at 760mmHg
	分子式	C₁₇H₁₄N₂O	熔点	N/A
	MSDS	N/A	闪点	291.1ºC

9-hydroxyellipticine用途

9-hydroxyellipticine, also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines.

英文名	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
英文别名	更多

密度	1.349g/cm3
沸点	557.7ºC at 760mmHg
分子式	C₁₇H₁₄N₂O
分子量	262.30600
闪点	291.1ºC
精确质量	262.11100
PSA	48.91000
LogP	4.19170

9-hydroxyellipticine毒性英文版

6H-Pyrido[4,3-b...

10371-86-5

~67%

9-hydroxyellipticine

51131-85-2

文献：Anderson, Wayne K.; Gopalsamy, Ariamala; Reddy, Peech S. Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1955 - 1963

9-formylellipticine

115552-64-2

~93%

9-hydroxyellipticine

51131-85-2

文献：Plug; Koomen; Pandit Synthesis, 1992 , # 12 p. 1221 - 1222

5,11-dimethylpy...

76004-29-0

~93%

9-hydroxyellipticine

51131-85-2

文献：Pautet; Formisyn; Bourgois Archiv der Pharmazie, 1993 , vol. 326, # 8 p. 499 - 500

椭圆玫瑰树碱溶液

519-23-3

9-hydroxyellipticine

51131-85-2

文献：Plug; Koomen; Pandit Synthesis, 1992 , # 12 p. 1221 - 1222

9-hydroxyellipticine上游产品 4
CAS号10371-86-5 6H-Pyrido[4,3-b... CAS号115552-64-2 9-formylellipticine CAS号76004-29-0 5,11-dimethylpy... CAS号519-23-3 椭圆玫瑰树碱溶液
9-hydroxyellipticine下游产品 3
CAS号76004-29-0 5,11-dimethylpy... CAS号102353-63-9 5,11-dimethyl-6... CAS号86542-48-5 10-((5,11-dimet...