9-hydroxyellipticine

Modify Date: 2025-08-25 17:51:58

9-hydroxyellipticine structure	Common Name	9-hydroxyellipticine
	CAS Number	51131-85-2	Molecular Weight	262.30600
	Density	1.349g/cm3	Boiling Point	557.7ºC at 760mmHg
	Molecular Formula	C₁₇H₁₄N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	291.1ºC

Use of 9-hydroxyellipticine

9-hydroxyellipticine, also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines.

Name	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
Synonym	More Synonyms

Density	1.349g/cm3
Boiling Point	557.7ºC at 760mmHg
Molecular Formula	C₁₇H₁₄N₂O
Molecular Weight	262.30600
Flash Point	291.1ºC
Exact Mass	262.11100
PSA	48.91000
LogP	4.19170
InChIKey	QZTWUDDGLIDXSE-UHFFFAOYSA-N
SMILES	Cc1c2ccncc2c(C)c2c1[nH]c1ccc(O)cc12

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8886500

CHEMICAL NAME :: 6H-Pyrido(4,3-b)carbazol-9-ol, 5,11-dimethyl-

CAS REGISTRY NUMBER :: 51131-85-2

LAST UPDATED :: 199410

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C17-H14-N2-O

MOLECULAR WEIGHT :: 262.33

WISWESSER LINE NOTATION :: T D6 B656 FM KMJ C1 J1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg/11D-I

TOXIC EFFECTS :: Blood - leukopenia Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 1 ug/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3544,1983

6H-Pyrido[4,3-b...

CAS#:10371-86-5

~67%

9-hydroxyellipticine

CAS#:51131-85-2

Literature: Anderson, Wayne K.; Gopalsamy, Ariamala; Reddy, Peech S. Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1955 - 1963

9-formylellipticine

CAS#:115552-64-2

~93%

9-hydroxyellipticine

CAS#:51131-85-2

Literature: Plug; Koomen; Pandit Synthesis, 1992 , # 12 p. 1221 - 1222

5,11-dimethylpy...

CAS#:76004-29-0

~93%

9-hydroxyellipticine

CAS#:51131-85-2

Literature: Pautet; Formisyn; Bourgois Archiv der Pharmazie, 1993 , vol. 326, # 8 p. 499 - 500

ELLIPTICINE

CAS#:519-23-3

9-hydroxyellipticine

CAS#:51131-85-2

Literature: Plug; Koomen; Pandit Synthesis, 1992 , # 12 p. 1221 - 1222

Precursor 4
CAS#:10371-86-5 6H-Pyrido[4,3-b... CAS#:115552-64-2 9-formylellipticine CAS#:76004-29-0 5,11-dimethylpy... CAS#:519-23-3 ELLIPTICINE
DownStream 3
CAS#:76004-29-0 5,11-dimethylpy... CAS#:102353-63-9 5,11-dimethyl-6... CAS#:86542-48-5 10-((5,11-dimet...

Name: Cytotoxicity against H 358 human lung cancer cell line
Source: ChEMBL
Target: NCI-H358
External Id: CHEMBL871939

Name: The effective dose against L1210 cell growth
Source: ChEMBL
Target: L1210
External Id: CHEMBL885248

Name: The effect on oxygen uptake in the presence of MPO-H2O2 at pH 7.8
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL722952

Name: The effect on oxygen uptake in the presence of MPO-H2O2 at pH 6.0
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL722951

Name: Cytotoxicity against H 460 human lung cancer cell line
Source: ChEMBL
Target: NCI-H460
External Id: CHEMBL880109

Name: The effect on oxygen uptake in the presence of MPO-H2O2 at pH 6.8
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL722954

Name: The effect on oxygen uptake in the presence of MPO-H2O2 at pH 8.3
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL722953

Name: The effect on oxygen uptake in the presence of MPO-H2O2 without the compound at pH 6....
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL879907

Name: DNA binding dissociation constant as KD
Source: ChEMBL
Target: Nucleic Acid
External Id: CHEMBL635338

Name: The effect on oxygen uptake in the presence of MPO-H2O2 at pH 7.4
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL722955

Total 54, Current Page 1 of 6

ELLIPTICINE,9-HYDROXY

9-Hydroxyellipticin

9-Hydroxyellipticine

EINECS 257-000-0

9-hydroxyelipticine

IGIG 929

Hydroxyellipticine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6H-Pyrido[4,3-b]carbazol-9-ol,5,11-dimethyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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9-hydroxyellipticine

Use of 9-hydroxyellipticine

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Synthetic Route

Precursor & DownStream

9-hydroxyellipticineBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.