次大风子素

• 常用名: 次大风子素
• 英文名: Rac-Hydnocarpin
• CAS号: 51419-48-8
• 分子量: 464.421
• 密度: 1.5±0.1 g/cm3
• 沸点: 740.9±60.0 °C at 760 mmHg
• 分子式: C₂₅H₂₀O₉
• 熔点: N/A
• 闪点: 257.8±26.4 °C

次大风子素用途

Rac-Hydnocarpin 是从大风子树种分离得到的黄酮类化合物,对癌细胞具有中等的细胞毒性。

次大风子素名称

• 中文名: 次大风子素
• 英文名: 5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one

次大风子素生物活性

• 描述: Rac-Hydnocarpin 是从大风子树种分离得到的黄酮类化合物,对癌细胞具有中等的细胞毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Arya JS, et al. Exploring Mitochondria-Mediated Intrinsic Apoptosis by New Phytochemical Entities: An Explicit Observation of Cytochrome c Dynamics on Lung and Melanoma Cancer Cells. J Med Chem. 2019 Sep 12;62(17):8311-8329.

次大风子素物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 740.9±60.0 °C at 760 mmHg
• 分子式: C₂₅H₂₀O₉
• 分子量: 464.421
• 闪点: 257.8±26.4 °C
• 精确质量: 464.110718
• PSA: 138.82000
• LogP: 2.66
• InChIKey: NMICSFNNFDNGEL-UHFFFAOYSA-N
• SMILES: COc1cc(C2Oc3ccc(-c4cc(=O)c5c(O)cc(O)cc5o4)cc3OC2CO)ccc1O
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.685
• 储存条件: 室温

次大风子素靶点实验

查看更多实验

实验名称：Hypolipidemic activity in CF1 mouse assessed as serum cholesterol level at 150 mg/kg/... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1014789

实验名称：Hypolipidemic activity in CF1 mouse assessed as serum cholesterol level at 8 mg/kg/da... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1014786

实验名称：Hypolipidemic activity in CF1 mouse assessed as serum cholesterol level at 8 mg/kg/da... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1014785

实验名称：Minimum inhibitory concentration, that inhibits growth of Staphylococcus aureus in th... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL800971

实验名称：Antiinflammatory activity against CF1 mouse assessed as inhibition of carrageenan-ind... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1014791

实验名称：Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：KM-20L2 External Id：CHEMBL1027458

实验名称：Cytotoxicity against human DU145 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL1027459

实验名称：In vivo antineoplastic activity against mouse Ehrlich ascite carcinoma cells xenograf... 来源：ChEMBL 靶标：Ehrlich External Id：CHEMBL1014835

实验名称：Cytotoxicity against human SF268 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：SF-268 External Id：CHEMBL1027456

实验名称：Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL1027457

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次大风子素英文别名

• 5,7-Dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4H-chromen-4-one
• 4H-1-Benzopyran-4-one,2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-5,7-dihydroxy-,trans
• 5,7-dihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one