马里苷

• 常用名: 马里苷
• 英文名: Marein
• CAS号: 535-96-6
• 分子量: 450.393
• 密度: 1.7±0.1 g/cm3
• 沸点: 835.4±65.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂O₁₁
• 熔点: 197-202ºC
• 闪点: 293.5±27.8 °C

马里苷用途

Marein 通过减少对线粒体功能的损害和 AMPK 信号通路的激活而具有神经保护作用。Marein 通过 CaMKK/AMPK/GLUT1 促进葡萄糖摄取,通过 IRS/Akt/GSK-3β 增加糖原合成,并通过 Akt/FoxO1 减少糖异生,从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。Marein 是一种 HDAC 抑制剂,IC50 为 100 µM。Marein 具有有益的抗氧化,降压,降血脂和抗糖尿病作用。

马里苷名称

• 中文名: 马里苷
• 英文名: marein

马里苷生物活性

• 描述: Marein 通过减少对线粒体功能的损害和 AMPK 信号通路的激活而具有神经保护作用。Marein 通过 CaMKK/AMPK/GLUT1 促进葡萄糖摄取,通过 IRS/Akt/GSK-3β 增加糖原合成,并通过 Akt/FoxO1 减少糖异生,从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。Marein 是一种 HDAC 抑制剂,IC50 为 100 µM。Marein 具有有益的抗氧化,降压,降血脂和抗糖尿病作用。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  研究领域 >> 心血管疾病
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
  研究领域 >> 代谢疾病
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  研究领域 >> 神经疾病
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  IC50: 100 µM (HDAC)[3]

• 参考文献:

  [1]. Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900.

  [2]. Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187.

  [3]. B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.

马里苷物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 835.4±65.0 °C at 760 mmHg
• 熔点: 197-202ºC
• 分子式: C₂₁H₂₂O₁₁
• 分子量: 450.393
• 闪点: 293.5±27.8 °C
• 精确质量: 450.116211
• PSA: 197.37000
• LogP: -0.18
• InChIKey: XGEYXJDOVMEJNG-HTFDPZBKSA-N
• SMILES: O=C(C=Cc1ccc(O)c(O)c1)c1ccc(OC2OC(CO)C(O)C(O)C2O)c(O)c1O
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.751
• 储存条件: 室温

马里苷安全信息

• 危害码 (欧洲): Xi

马里苷靶点实验

查看更多实验

实验名称：Inhibition of electric eel AChE at 2 mg/ml by Ellman's method 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL2166270

实验名称：Inhibition of horse BChE at 2 mg/ml by Ellman's method 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL2166271

实验名称：Confirmatory firefly luciferase (FLuc) qHTS assay for identification of artifact comp... 来源：NCGC External Id：art-modeling-FLuc-f1

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：qHTS for Inhibitors of binding or entry into cells for Marburg Virus 来源：NCGC 靶标：gene 4 small orf - Marburg virus External Id：VSVM-OFFLINE

实验名称：qHTS for Inhibitors of binding or entry into cells for Lassa Virus 来源：NCGC 靶标：N/A External Id：VSVL-OFFLINE

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马里苷英文别名

• 4-[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]-2,3-dihydroxyphenyl β-D-glucopyranoside
• β-D-Glucopyranoside de 4-[(2E)-3-(3,4-dihydroxyphényl)-2-propènan-1-oyl]-2,3-dihydroxyphényle
• Okanin-4'-O-glucoside
• (2E)-3-(3,4-Dihydroxyphenyl)-1-(2,3-dihydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}phenyl)-2-propen-1-one
• (E)-3-(3,4-Dihydroxyphenyl)-1-(4-(β-D-glucopyranosyloxy)-2,3-dihydroxyphenyl)-2-propen-1-one
• (2E)-3-(3,4-Dihydroxyphényl)-1-(2,3-dihydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}phényl)-2-propén-1-one
• 4-[(2E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]-2,3-dihydroxyphenyl β-D-glucopyranoside
• (2E)-3-(3,4-Dihydroxyphenyl)-1-(2,3-dihydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}phenyl)-2-propen-1-on
• 4-[(2E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]-2,3-dihydroxyphenyl b-D-glucopyranoside
• Okanin-4'-glucoside
• 4-[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]-2,3-dihydroxyphenyl-β-D-glucopyranoside
• Marein
• 2',3,3',4,4'-pentahydroxy-4'-glucosylchalcone