N-(2-氨基苯基)-N'-苯基庚二酰胺

• 常用名: N-(2-氨基苯基)-N'-苯基庚二酰胺
• 英文名: N-(2-Aminophenyl)-N'-phenylheptanediamide
• CAS号: 537034-15-4
• 分子量: 325.40500
• 密度: 1.213g/cm3
• 沸点: 627.86ºC at 760 mmHg
• 分子式: C₁₉H₂₃N₃O₂
• 熔点: N/A
• 闪点: 333.518ºC

N-(2-氨基苯基)-N'-苯基庚二酰胺用途

NKL 22是HDAC抑制剂

N-(2-氨基苯基)-N'-苯基庚二酰胺名称

• 中文名: NKL 22
• 英文名: N'-(2-aminophenyl)-N-phenylheptanediamide

N-(2-氨基苯基)-N'-苯基庚二酰胺生物活性

• 描述: NKL 22是HDAC抑制剂
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  HDAC:78 μM (IC50, in HeLa nuclear)

• 参考文献:

  [1]. D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.

N-(2-氨基苯基)-N'-苯基庚二酰胺物理化学性质

• 密度: 1.213g/cm3
• 沸点: 627.86ºC at 760 mmHg
• 分子式: C₁₉H₂₃N₃O₂
• 分子量: 325.40500
• 闪点: 333.518ºC
• 精确质量: 325.17900
• PSA: 91.20000
• LogP: 5.67670
• InChIKey: ZAIULUYKQLVQFH-UHFFFAOYSA-N
• SMILES: Nc1ccccc1NC(=O)CCCCCC(=O)Nc1ccccc1
• 外观性状: white solid
• 折射率: 1.644
• 储存条件: -20℃

N-(2-氨基苯基)-N'-苯基庚二酰胺靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGF... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL5303712

实验名称：Induction of alpha tubulin hyperacetylation in human U937 cells at 5 uM 来源：ChEMBL 靶标：U-937 External Id：CHEMBL936423

实验名称：Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 1... 来源：ChEMBL 靶标：Histone deacetylase 5 External Id：CHEMBL1227050

实验名称：Induction of histone H4 hyperacetylation in human U937 cells at 5 uM 来源：ChEMBL 靶标：U-937 External Id：CHEMBL936415

实验名称：Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 8... 来源：ChEMBL 靶标：Histone deacetylase 5 External Id：CHEMBL1227049

实验名称：Inhibition of HDAC in human GM15850 cells assessed as increase in histone H3 lysine 9... 来源：ChEMBL 靶标：Histone deacetylase 5 External Id：CHEMBL1227048

实验名称：Induction of granulocytic differentiation in human U937 cells assessed as CD11c expre... 来源：ChEMBL 靶标：U-937 External Id：CHEMBL936424

实验名称：Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 1... 来源：ChEMBL 靶标：Histone deacetylase 5 External Id：CHEMBL1227047

实验名称：Inhibition of human HDAC1 in U937 cells at 5 uM 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL936420

实验名称：Inhibition of HDAC in human GM15850 cells assessed as increase in histone H4 lysine 5... 来源：ChEMBL 靶标：Histone deacetylase 5 External Id：CHEMBL1227045

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N-(2-氨基苯基)-N'-苯基庚二酰胺英文别名

• IN1468
• Histone Deacetylase Inhibitor IV
• NKL 22
• N-(2-Aminophenyl)-N'-phenylheptanediamide
• HDAC inhibitor IV