毛束草碱

• 常用名: 毛束草碱
• 英文名: Trichodesmine
• CAS号: 548-90-3
• 分子量: 239.09700
• 密度: 1.29g/cm3
• 沸点: 546.5ºC at 760 mmHg
• 分子式: C₁₂H₈Cl₂O
• 熔点: 160-161 °C
• 闪点: 284.3ºC

毛束草碱用途

毛地胺是一种去氢吡咯里西啶生物碱。毛地胺在体内可产生肝毒性、肺毒性和神经毒性[1][2]。

毛束草碱名称

• 中文名: 毛束草碱
• 英文名: 2-chloro-4-(4-chlorophenyl)phenol

毛束草碱生物活性

• 描述: 毛地胺是一种去氢吡咯里西啶生物碱。毛地胺在体内可产生肝毒性、肺毒性和神经毒性[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
• 体外研究: 毛地胺在驴子身上产生肺和肝损伤[2]。
• 参考文献:

  [1]. Cooper RA, et, al. The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity. Proc West Pharmacol Soc. 1999;42:13-6.

  [2]. Pessoa CRM, et, al. Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys. Toxicon. 2013 Sep;71:113-20.

毛束草碱物理化学性质

• 密度: 1.29g/cm3
• 沸点: 546.5ºC at 760 mmHg
• 熔点: 160-161 °C
• 分子式: C₁₂H₈Cl₂O
• 分子量: 239.09700
• 闪点: 284.3ºC
• 精确质量: 237.99500
• PSA: 20.23000
• LogP: 4.36600
• InChIKey: SOODLZHDDSGRKL-FOOXYVKASA-N
• SMILES: CC(C)C1C(=O)OC2CCN3CC=C(COC(=O)C(C)(O)C1(C)O)C23
• 外观性状: 粉末
• 折射率: 1.571
• 储存条件: 2-8°C， 密封， 干燥， 避光

毛束草碱安全信息

• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)

毛束草碱靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：USP8 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 8 External Id：USP8 FAST DUB HTS Primary

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：USP17 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 7 External Id：USP7 FAST DUB HTS Primary

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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毛束草碱英文别名

• 3,4'-Dichloro-4-biphenylol
• Trichodesmine
• [1,1'-Biphenyl]-4-ol,3,4'-dichloro