Ulodesine

• 常用名: Ulodesine
• 英文名: Ulodesine
• CAS号: 548486-59-5
• 分子量: 264.28000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₆N₄O₃
• 熔点: N/A
• 闪点: N/A

Ulodesine用途

乌洛地辛是一种嘌呤核苷磷酸化酶(PNP)抑制剂。乌洛地辛抑制PNP,IC50值为2.293 nM/L。乌洛地辛可用于研究低冰血症[1][2]。

Ulodesine名称

• 英文名: 7-[[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one

Ulodesine生物活性

• 描述: 乌洛地辛是一种嘌呤核苷磷酸化酶(PNP)抑制剂。乌洛地辛抑制PNP,IC50值为2.293 nM/L。乌洛地辛可用于研究低冰血症[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
• 体内研究: 乌洛地平(i.v.)有效抑制PNP,IC50值为2.293 nM/L[1]。乌洛地辛(i.v.)消除了小鼠模型血液中的尿酸积聚[1]。

Ulodesine物理化学性质

• 分子式: C₁₂H₁₆N₄O₃
• 分子量: 264.28000
• 精确质量: 264.12200
• PSA: 105.50000
• InChIKey: AFNHHLILYQEHKK-BDAKNGLRSA-N
• SMILES: O=c1[nH]cnc2c(CN3CC(O)C(CO)C3)c[nH]c12

Ulodesine靶点实验

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实验名称：Inhibition of human PNP 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL931720

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Inhibition of human PNP by xanthine-oxidase coupled assay 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL951777

实验名称：Inhibition of Plasmodium falciparum purine nucleoside phosphorylase assessed as slow ... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL982802

实验名称：Inhibition of bovine PNP 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL931721

实验名称：Binding affinity to human PNP assessed as inhibition constant by TR-FRET assay 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL5551563

实验名称：Inhibition of Plasmodium falciparum PNP 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL931722

实验名称：Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assay 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL982801

实验名称：Inhibition of human purine nucleoside phosphorylase assessed as slow onset inhibition... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL982800

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Ulodesine英文别名

• DADMe-ImmH,7
• BCX 4208
• ULODESINE
• 1n3i
• DADMe-immucillin H