海罂粟碱

• 常用名: 海罂粟碱
• 英文名: 2,3,5,6-Tetramethoxyaporphine
• CAS号: 5630-11-5
• 分子量: 355.42800
• 密度: 1.166g/cm3
• 沸点: 487ºC at 760 mmHg
• 分子式: C₂₁H₂₅NO₄
• 熔点: 119ºC
• 闪点: 140.2ºC

海罂粟碱用途

2,3,5,6-四甲氧基阿朴啡是一种镇咳药,是一种有药用价值的苄基异喹啉生物碱。2,3,5,6-四甲氧基阿朴啡可从黄色角罂粟(Glaucium flavum Cr)(罂粟科)[1][2]中分离得到。

海罂粟碱名称

• 中文名: 海罂粟碱
• 英文名: 1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

海罂粟碱生物活性

• 描述: 2,3,5,6-四甲氧基阿朴啡是一种镇咳药,是一种有药用价值的苄基异喹啉生物碱。2,3,5,6-四甲氧基阿朴啡可从黄色角罂粟(Glaucium flavum Cr)(罂粟科)[1][2]中分离得到。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Mohamed ME, et al. Plant germination and production of callus from the yellow hornpoppy (Glaucium flavum): the first stage of micropropagation. Pharmazie. 2014 Sep;69(9):715-20.

  [2]. Redpath JB, et al. Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers. Br J Clin Pharmacol. 1982 Oct;14(4):555-8.

海罂粟碱物理化学性质

• 密度: 1.166g/cm3
• 沸点: 487ºC at 760 mmHg
• 熔点: 119ºC
• 分子式: C₂₁H₂₅NO₄
• 分子量: 355.42800
• 闪点: 140.2ºC
• 精确质量: 355.17800
• PSA: 40.16000
• LogP: 3.41100
• InChIKey: RUZIUYOSRDWYQF-UHFFFAOYSA-N
• SMILES: COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3
• 折射率: 1.575

海罂粟碱靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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海罂粟碱英文别名

• (1)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline
• (+/-)-glaucine
• lauroscholtzine
• 1,2,9,10-tetramethoxyaporphine
• rac-1,2,9,10-tetramethoxy-6-methyl-aporphane
• glaucine phosphate
• tussiglaucin
• (+/-)-5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline