桑辛素 M

• 常用名: 桑辛素 M
• 英文名: Moracin M
• CAS号: 56317-21-6
• 分子量: 242.227
• 密度: 1.5±0.1 g/cm3
• 沸点: 369.3±22.0 °C at 760 mmHg
• 分子式: C₁₄H₁₀O₄
• 熔点: 271-273 ºC
• 闪点: 177.1±22.3 °C

桑辛素 M用途

Moracin M 是桑白皮中的一种酚类成分,有效的磷酸二酯酶 4 (PDE4) 抑制剂,对于 PDE4D2,PDE4B2,PDE5A1 和 PDE9A2 的 IC50 分别为 2.9 μM,4.5 μM,> 40 μM 和 > 100 μM。Moracin M 具有抗炎活性。

桑辛素 M名称

• 中文名: 桑辛素 M
• 英文名: 5-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol
• 中文别名: 2-(3,5-二羟基苯基)-6-羟基苯并呋喃

桑辛素 M生物活性

• 描述: Moracin M 是桑白皮中的一种酚类成分,有效的磷酸二酯酶 4 (PDE4) 抑制剂,对于 PDE4D2,PDE4B2,PDE5A1 和 PDE9A2 的 IC50 分别为 2.9 μM,4.5 μM,> 40 μM 和 > 100 μM。Moracin M 具有抗炎活性。
• 靶点实验:

  PDE4D2:2.9 μM (IC50)

  PDE4B2:4.5 μM (IC50)

  PDE5A1:>40 μM (IC50)

  PDE9A2:>100 μM (IC50)

  Human Endogenous Metabolite

• 参考文献:

  [1]. Chen SK, et al. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4.

桑辛素 M物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 369.3±22.0 °C at 760 mmHg
• 熔点: 271-273 ºC
• 分子式: C₁₄H₁₀O₄
• 分子量: 242.227
• 闪点: 177.1±22.3 °C
• 精确质量: 242.057907
• PSA: 73.83000
• LogP: 2.37
• InChIKey: LHPRYOJTASOZGJ-UHFFFAOYSA-N
• SMILES: Oc1cc(O)cc(-c2cc3ccc(O)cc3o2)c1
• 外观性状: 棕色粉末
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.730
• 储存条件: 室温
• 水溶解性: Very slightly soluble (0.18 g/L) (25 ºC)

桑辛素 M安全信息

• 危害码 (欧洲): Xi

桑辛素 M靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Meas... 来源：Broad Institute 靶标：FGF22 human recombinant External Id：7012-04_Inhibitor_Dose_CherryPick_Activity

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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桑辛素 M英文别名

• Veraphenol
• 5-(6-Hydroxy-benzofuran-2-yl)-benzene-1,3-diol
• Moracin M
• 5-(6-Hydroxy-1-benzofuran-2-yl)-1,3-benzenediol
• 5-(6-Hydroxy-1-benzofuran-2-yl)benzene-1,3-diol
• 2-(3,5-Dihydroxyphenyl)-6-hydroxybenzofuran