SB297006

更新时间：2025-08-25 09:21:25

SB297006结构式	常用名	SB297006	英文名	SB297006
	CAS号	58816-69-6	分子量	342.34600
	密度	N/A	沸点	N/A
	分子式	C₁₈H₁₈N₂O₅	熔点	121 °C
	MSDS	中文版美版	闪点	N/A
	符号	GHS07, GHS09	信号词	Warning

SB297006用途

SB297006 是一种 CCR3 拮抗剂,能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。

中文名	SB297006
英文名	sb 297006
英文别名	更多

描述	SB297006 是一种 CCR3 拮抗剂,能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。
相关类别	研究领域 >> 神经疾病
靶点实验	CCR3[1]
体外研究	SB297006是一种CCR3拮抗剂,在100μM时显着抑制CCL11处理的神经祖细胞(NPC)中的增殖和神经球形成[1]。
细胞实验	为了评估CCR3阻断，将神经祖细胞（NPC）与CCR3拮抗剂SB297006（100μM）一起温育30分钟，然后用CCL11（2μg/ mL）刺激。培养3天后，对NPC进行CCK-8测定[1]。
参考文献	[1]. Wang F, et al. CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem Cell Res Ther. 2017 Feb 7;8(1):26.

熔点	121 °C
分子式	C₁₈H₁₈N₂O₅
分子量	342.34600
精确质量	342.12200
PSA	101.22000
LogP	3.41310
InChIKey	BEZXGSZPWXRHIN-INIZCTEOSA-N
SMILES	CCOC(=O)C(Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccccc1
外观性状	固体;White to Almost white powder to crystal
储存条件	0-10°C;避免加热

符号	GHS07, GHS09
信号词	Warning
危害声明	H302-H400
警示性声明	P273
危险品运输编码	UN 3077 9 / PGIII

SB297006上游产品 0
SB297006下游产品 1
CAS号943-80-6 4-氨基-L-苯丙氨酸

CCR3 antagonists: a survey of the patent literature.

Expert Opin. Ther. Pat. 19(8) , 1109-32, (2009)

Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease.A p...

Cytokine modulators as novel therapies for asthma.

Annu. Rev. Pharmacol. Toxicol. 42 , 81-98, (2002)

Cytokines play a critical role in orchestrating and perpetuating inflammation in asthmatic airways and several specific cytokine and chemokine inhibitors are now in development for the treatment of as...

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate
来源：ChEMBL
靶标：Histone deacetylase 6
External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate
来源：ChEMBL
靶标：Histone deacetylase 6
External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4513082

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3301363

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4303805

实验名称：Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125...
来源：ChEMBL
靶标：C-C chemokine receptor type 3
External Id：CHEMBL650420

实验名称：Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent...
来源：ChEMBL
靶标：HepG2
External Id：CHEMBL5303715

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
来源：ChEMBL
靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

共8条，当前第1页，共1页

n-benzoyl-4-nitroaniline ethyl ester