NEK6 inibitor 8

• 常用名: NEK6 inibitor 8
• 英文名: NEK6 inibitor 8
• CAS号: 591239-68-8
• 分子量: 304.299
• 密度: 1.3±0.1 g/cm3
• 沸点: 504.9±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₂N₂O₃
• 熔点: N/A
• 闪点: 259.2±30.1 °C

NEK6 inibitor 8用途

NEK6 inibitor 8(ZINC05007751)是NIMA相关激酶NEK6的新型抑制剂,IC50为3.4 uM,化合物8对NEK1和NEK6具有很强的选择性,而对NEK2,NEK7和NEK9没有观察到显着活性；对一组人癌细胞系的分散抗增殖活性(IC50<100 uM)。

NEK6 inibitor 8名称

• 英文名: (5Z)-2-Hydroxy-4-methyl-6-oxo-5-[(5-phenyl-2-furyl)methylene]-5,6-dihydropyridine-3-carbonitrile

NEK6 inibitor 8生物活性

• 描述: NEK6 inibitor 8(ZINC05007751)是NIMA相关激酶NEK6的新型抑制剂,IC50为3.4 uM,化合物8对NEK1和NEK6具有很强的选择性,而对NEK2,NEK7和NEK9没有观察到显着活性；对一组人癌细胞系的分散抗增殖活性(IC50<100 uM)。
• 参考文献: References 1. De Donato M, et al. Sci Rep. 2018 Oct 30;8(1):16047. View Related Products by Target Other Targets

NEK6 inibitor 8物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 504.9±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₂N₂O₃
• 分子量: 304.299
• 闪点: 259.2±30.1 °C
• 精确质量: 304.084778
• LogP: 3.44
• InChIKey: SNLNUUWCOAPJED-ZROIWOOFSA-N
• SMILES: CC1=C(C#N)C(=O)NC(=O)C1=Cc1ccc(-c2ccccc2)o1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.646
• 储存条件: -20°C，密闭，干燥

NEK6 inibitor 8靶点实验

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实验名称：Synergistic cytotoxicity against human PEO1 cells assessed as combination index at 44... 来源：ChEMBL 靶标：PEO1 External Id：CHEMBL4807549

实验名称：Synergistic cytotoxicity against human PEO1 cells assessed as combination index at 44... 来源：ChEMBL 靶标：PEO1 External Id：CHEMBL4807550

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Synergistic cytotoxicity against human PEO1 cells assessed as combination index at 44... 来源：ChEMBL 靶标：PEO1 External Id：CHEMBL4807543

实验名称：Synergistic cytotoxicity against human PEO1 cells assessed as combination index at 44... 来源：ChEMBL 靶标：PEO1 External Id：CHEMBL4807544

实验名称：Synergistic cytotoxicity against human PEO1 cells assessed as combination index at 44... 来源：ChEMBL 靶标：PEO1 External Id：CHEMBL4807541

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Synergistic cytotoxicity against human PEO1 cells assessed as combination index at 44... 来源：ChEMBL 靶标：PEO1 External Id：CHEMBL4807542

实验名称：Synergistic cytotoxicity against human PEO1 cells assessed as combination index at 44... 来源：ChEMBL 靶标：PEO1 External Id：CHEMBL4807547

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

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NEK6 inibitor 8英文别名

• (5Z)-2-Hydroxy-4-methyl-6-oxo-5-[(5-phenyl-2-furyl)methylene]-5,6-dihydropyridine-3-carbonitrile
• (5Z)-4-Methyl-2,6-dioxo-5-[(5-phenyl-2-furyl)methylene]-1,2,5,6-tetrahydro-3-pyridinecarbonitrile