NEK6 inibitor 8

Modify Date: 2024-01-15 00:25:54

NEK6 inibitor 8 Structure
NEK6 inibitor 8 structure
 Common Name NEK6 inibitor 8
CAS Number 591239-68-8 Molecular Weight 304.299
Density 1.3±0.1 g/cm3 Boiling Point 504.9±50.0 °C at 760 mmHg
Molecular Formula C18H12N2O3 Melting Point N/A
MSDS N/A Flash Point 259.2±30.1 °C

 Use of NEK6 inibitor 8


NEK6 inibitor 8 (ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9; dispalys antiproliferative activity against a panel of human cancer cell lines (IC50 <100 uM).

 Names

Name (5Z)-2-Hydroxy-4-methyl-6-oxo-5-[(5-phenyl-2-furyl)methylene]-5,6-dihydropyridine-3-carbonitrile
Synonym More Synonyms

 NEK6 inibitor 8 Biological Activity

Description NEK6 inibitor 8 (ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9; dispalys antiproliferative activity against a panel of human cancer cell lines (IC50 <100 uM).
References References 1. De Donato M, et al. Sci Rep. 2018 Oct 30;8(1):16047. View Related Products by Target Other Targets

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 504.9±50.0 °C at 760 mmHg
Molecular Formula C18H12N2O3
Molecular Weight 304.299
Flash Point 259.2±30.1 °C
Exact Mass 304.084778
LogP 3.44
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.646

 Synonyms

(5Z)-2-Hydroxy-4-methyl-6-oxo-5-[(5-phenyl-2-furyl)methylene]-5,6-dihydropyridine-3-carbonitrile
3-Pyridinecarbonitrile, 1,2,5,6-tetrahydro-4-methyl-2,6-dioxo-5-[(5-phenyl-2-furanyl)methylene]-, (5Z)-
3-pyridinecarbonitrile, 5,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-[(5-phenyl-2-furanyl)methylene]-, (5Z)-
(5Z)-4-Methyl-2,6-dioxo-5-[(5-phenyl-2-furyl)methylene]-1,2,5,6-tetrahydro-3-pyridinecarbonitrile
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