5-乙炔基尿嘧啶

• 常用名: 5-乙炔基尿嘧啶
• 英文名: Eniluracil
• CAS号: 59989-18-3
• 分子量: 136.10800
• 密度: 1.39g/cm3
• 沸点: N/A
• 分子式: C₆H₄N₂O₂
• 熔点: 320 °C(dec.)
• 闪点: N/A

5-乙炔基尿嘧啶用途

Eniluracil (5-Ethynyluracil),尿嘧啶类似物,一种不可逆的二氢嘧啶脱氢酶 (DPD) 抑制剂,使 5-FU 的口服生物利用度提高到 100%,促进均匀吸收和可预测的毒性。

5-乙炔基尿嘧啶名称

• 中文名: 5-乙炔-2,4(1h,3H-)-嘧啶二酮(9ci)
• 英文名: 5-ethynyl-1H-pyrimidine-2,4-dione

5-乙炔基尿嘧啶生物活性

• 描述: Eniluracil (5-Ethynyluracil),尿嘧啶类似物,一种不可逆的二氢嘧啶脱氢酶 (DPD) 抑制剂,使 5-FU 的口服生物利用度提高到 100%,促进均匀吸收和可预测的毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  Dihydropyrimidine dehydrogenase[1]

• 参考文献:

  [1]. Schilsky RL, et al. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.

5-乙炔基尿嘧啶物理化学性质

• 密度: 1.39g/cm3
• 熔点: 320 °C(dec.)
• 分子式: C₆H₄N₂O₂
• 分子量: 136.10800
• 精确质量: 136.02700
• PSA: 65.72000
• InChIKey: JOZGNYDSEBIJDH-UHFFFAOYSA-N
• SMILES: C#Cc1c[nH]c(=O)[nH]c1=O
• 外观性状: 固体;White to Light yellow to Light orange powder to crystal
• 折射率: 1.589
• 储存条件: 室温，干燥

5-乙炔基尿嘧啶靶点实验

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实验名称：Inactivation of bovine liver DHPDHase assessed as Kinact in presence of NADPH 来源：ChEMBL 靶标：Dihydropyrimidine dehydrogenase [NADP(+)] External Id：CHEMBL4617528

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Inhibitory activity against dihydropyrimidine dehydrogenase (DPD) 来源：ChEMBL 靶标：Dihydropyrimidine dehydrogenase [NADP(+)] External Id：CHEMBL665825

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

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5-乙炔基尿嘧啶英文别名

• ethynyluracil
• 5-ETHYNYLURACIL
• Compound 776C
• Eniluracil
• ethynyluracyl
• GW776C85
• 776C85