芫花酯甲

• 常用名: 芫花酯甲
• 英文名: Yuanhuacine
• CAS号: 60195-70-2
• 分子量: 648.73900
• 密度: 1.35g/cm3
• 沸点: 765.9ºC at 760 mmHg
• 分子式: C₃₇H₄₄O₁₀
• 熔点: N/A
• 闪点: 236.9ºC

芫花酯甲用途

Yuanhuacine (Gnidilatidin),一种来自 Daphne genkwa 的达芙烷二萜,具有广泛的抗肿瘤活性。Yuanhuacine 是一种具有口服活性的的 DNA 损伤剂。

芫花酯甲名称

• 中文名: 芫花酯甲
• 英文名: Yuanhuacine

芫花酯甲生物活性

• 描述: Yuanhuacine (Gnidilatidin),一种来自 Daphne genkwa 的达芙烷二萜,具有广泛的抗肿瘤活性。Yuanhuacine 是一种具有口服活性的的 DNA 损伤剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368.

  [2]. Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403.

芫花酯甲物理化学性质

• 密度: 1.35g/cm3
• 沸点: 765.9ºC at 760 mmHg
• 分子式: C₃₇H₄₄O₁₀
• 分子量: 648.73900
• 闪点: 236.9ºC
• 精确质量: 648.29300
• PSA: 144.28000
• LogP: 3.70440
• InChIKey: CGSGRJNIABXQJQ-ZQLWRUAFSA-N
• SMILES: C=C(C)C12OC3(C=CC=CCCCCC)OC1C1C4OC4(CO)C(O)C4(O)C(=O)C(C)=CC4C1(O3)C(C)C2OC(=O)c1ccccc1
• 折射率: 1.633
• 储存条件: 2-8°C

芫花酯甲毒性和生态

芫花酯甲靶点实验

查看更多实验

实验名称：Cytotoxicity against human SH-SY5Y cells assessed as decrease in cell viability at hi... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854553

实验名称：Neuroprotective activity against 6-OHDA-induced cell death in human SH-SY5Y cells ass... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854554

实验名称：Antiinflammatory activity in mouse BV2 cells assessed as downregulation of LPS-induce... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854555

实验名称：Antiinflammatory activity in mouse BV2 cells assessed as downregulation of LPS-induce... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854556

实验名称：Activation of mouse Nurr1 transfected in human SK-N-BE(2)C cells at 0.3 uM by lucifer... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL3854549

实验名称：Cytotoxicity against human SK-N-BE(2)C cells up to 30 uM 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854550

实验名称：Activation of mouse Nurr1 transfected in human SK-N-BE(2)C cells at 0.3 uM in presenc... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL3854551

实验名称：Neuroprotective activity against 6-OHDA-induced cell death in human SH-SY5Y cells ass... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854552

实验名称：Antiinflammatory activity in 6-OHDA-lesioned Sprague-Dawley rat model of parkinson di... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854561

实验名称：Antiinflammatory activity in mouse BV2 cells assessed as downregulation of LPS-induce... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3854557

共18条，当前第1页，共2页

1

2

芫花酯甲英文别名

• Odoracin
• From gnidia
• gnidilatidin
• Stillingia factor S6,gnidilatidin