GNF-1331

• 常用名: GNF-1331
• 英文名: GNF-1331
• CAS号: 603101-22-0
• 分子量: 440.542
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₀N₆O₂S₂
• 熔点: N/A
• 闪点: N/A

GNF-1331用途

GNF-1331 is a Potent, Selective, and Orally Bioavailable Porcupine Inhibitor (IC50 = 12 nM). Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.

GNF-1331名称

• 英文名: gnf-1331

GNF-1331物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₀H₂₀N₆O₂S₂
• 分子量: 440.542
• 精确质量: 440.108917
• LogP: 4.35
• 折射率: 1.724

GNF-1331英文别名

• MFCD03750964
• Acetamide, N-(6-methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-
• gnf-1331
• N-(6-Methoxy-1,3-benzothiazol-2-yl)-2-{[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
• N-(6-Methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-acetamide